STUDY ON FOSFOMYCIN-SODIUM-SALT

Basic and clinical studies were conducted on FOM-Na. The MIC was low especially against Proteus spp. High blood concentrations were obtained following intravenous one shot administration, intravenous drip-infusion, and intrathorax administration, being considered effective against most of the organi...

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Published inCHEMOTHERAPY Vol. 23; no. 11; pp. 3316 - 3326
Main Authors SHIMIZU, TATSUNORI, TAKAGI, YASUO, SAITO, NAGANORI, YOKOYAMA, MICHIO, KOBAYASHI, TAKESHI, HIRAI, HIDEYUKI, ANZAI, TSUTOMU, SAITO, NOBUTERU, ONUMA, HIROAKI, NITTA, HIDEAKI
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1975
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Summary:Basic and clinical studies were conducted on FOM-Na. The MIC was low especially against Proteus spp. High blood concentrations were obtained following intravenous one shot administration, intravenous drip-infusion, and intrathorax administration, being considered effective against most of the organisms tested for MIC. FOM was excreted in the urine at high concentration, the excretion rate was good, and more than 90% of the given dose were excreted within 12 hours after administration. The excretion route of FOM is considered through the kidney. The active substance in the blood, urine, saliva, and pleural effusion was inferred to be FOM according to the spot obtained in the bioautogram of TLC. The clinical result showed both effective and poor cases, though the number of cases was small. No side effects.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.23.3316