ASSESSMENT OF THE DRUG ABSORPTION ROUTE AFTER AN INTRAPERITONEAL INJECTION OF CISPLATIN Effect of the Volume of Diluted Solution

An experiment was carried out in dogs to study the effect of the volume of a dilute solution on the drug absorption route after an intraperitoneal injection of cisplatin. Groups A and B, each consisting of five animals, were given cisplatin, 2 mg/kg, respectively, of physiological saline. Intraperit...

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Bibliographic Details
Published inJournal of The Showa Medical Association Vol. 57; no. 1; pp. 24 - 29
Main Authors KOH, Youmo, NAMATAME, Kimio
Format Journal Article
LanguageJapanese
Published The Showa University Society 28.02.1997
Subjects
absorotion route of cisplatin
cisplatin
intraperitoneal injection
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Summary:An experiment was carried out in dogs to study the effect of the volume of a dilute solution on the drug absorption route after an intraperitoneal injection of cisplatin. Groups A and B, each consisting of five animals, were given cisplatin, 2 mg/kg, respectively, of physiological saline. Intraperitoneal bolus injections of cisplatin were given with a 16-gauge catheter, after which cisplatin concentrations in the portal blood, peripheral blood, and liver tissue were measured. Results were as follows. 1) The portal free cisplatin concentration in group A tended to be higher than that in group B. 2) The peripheral total cisplatin concentration was lower in group A than that in group B. 3) The area under the curve results 1) and 2) . 4) The cisplatin concentration in liver tissue was high in group A. These results suggest that the intraperitoneal injection of cisplatin in a small volume of dilute solutionpromotes drug absorption into the portal system.
ISSN:0037-4342
2185-0976
DOI:10.14930/jsma1939.57.24