CLINICAL TRIALS OF FOSFOMYCIN IN CHILDREN

• Published in: CHEMOTHERAPY Vol. 23; no. 5; pp. 1854 - 1860
• Main Authors: NUNOUE, TADASU, GOYA, NAGAHIDE
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1975
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.23.1854

In 12 cases of children, including 2 cases of low birth weight infant, fosfomycin was given orally, and the efficacy was examined clinically. The dosage was 100mg/kg/day to 200mg/kg/day, divided 3 times daily respectively. Excellent effects were obtained in a case of staphylococcal osteomyelitis, which had been delayed to heal over during 60 days since onset in spite of injections with sensitive MCI-PC for 6 weeks, a case of staphylococcal scald skin syndrome, a case of biliary tract infection, which findings showed the complete obstructive jaundice, a case of diarrhea with E. coli and 2 cases of urinary tract infection, one of which was due to E. coli and the other with sensitive Pseudomonas bacilli. Urinary findings of the last case were relapsed with an alternated of resistant Klebsiella. Furunculosis with Staphylococcus aureus resistant to many antibiotics responded well to fosfomycin. Although the cocci on skin were eradicated, they were isolated from nostrils after 17 days administration of the drug. Generally the clinical response seems to be consistent with the sensitivity of pathogenic bacteria to fosfomycin. In this trials, Klebsiella infections were the most inadequate objects to give the new antibiotic. No serious side effect was recognized. Any unfavourable sign was not found in 2 low birth weight neonates, .though no desirable effect expected was gotten. As a minor one mild diarrhea was accompanied in an infant. The remarkable elevation of serum transaminase was occurred in a case of osteomyelitis, without any other abnormal findings in liver function test. The mechanism has been obscure, whether it was happened due to the damage of liver with the drug, or due to other cause. That is a problem to be clarified.