FUNDAMENTAL AND CLINICAL STUDIES ON TICARCILLIN

• Published in: CHEMOTHERAPY Vol. 25; no. 9; pp. 2681 - 2689
• Main Authors: YOSHIDA, TETSUNORI, OKIMOTO, YUICHIRO, OHURA, TAKEHIKO, IIDA, KAZUNORI, SAITO, AKIRA
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1977
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.25.9_2681

Fundamental experiments and clinical studies on ticarcillin were performed, and the following results were obtained. 1) The concentrations of ticarcillin in the skin and serum of rabbits were determined. (i) Intravenous administration of ticarcillin 100 mg/kg in one shot : The peak of concentration in serum was 217 μg/ml (mean value) 30 minutes after injection. On the other hand, the peak in skin was 138.1 μg/g (mean value) after 30 minutes. The ratio of concentration in the skin to the serum showed 64%. (ii) Drip infusion of ticarcillin 100 mg/kg in 1 hour : The peak of concentration was observed immediately after the administration, both in serum and skin. The ratio of the skin to the serum was 40%. 2) Ticarcillin, 750 mg to 6 g per day, was admininstered to the 12 cases (burned ulcer : 8, ulcer due to traffic accident : 1, post-operative ulcer : 1, decubitus : 1, post-operative pneumonia : 1). Ticarcillin was observed to be effective in 10 cases of 12. In a few cases, elevation of S-GOT, S-GPT and Al-P were observed, but it was not sure as a result of side effect or not. 3) Minimum inhibitory concentration of ticarcillin against Ps. aeruginosa isolated from the infective ulcers was examined. Ticarcillin was more effective than carbenicillin, 2-4 times. While in comparison to sulbenicillin, ticarcillin was same or twice in effectiveness.