Thrombosis with Thrombocytopenia Syndrome after ChAdOx1 nCoV-19 vaccination

A 48-year-old Japanese man who had no previous medical history received his first dose of the ChAdOx1 nCoV-19 vaccine. Ten days after the vaccine administration, he developed a headache. Laboratory results indicated throm-bocytopenia and DIC. A head CT revealed microbleeding in the left parietal lob...

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Bibliographic Details
Published inRinsho Shinkeigaku Vol. 62; no. 6; pp. 487 - 491
Main Authors Takatsuki, Mari, Araki, Toshihiko, Kanno, Akira, Yasumoto, Atsushi, Morishita, Eriko, Shiota, Hiroshi
Format Journal Article
LanguageJapanese
Published Japan Societas Neurologica Japonica 24.06.2022
Subjects
ChAdOx1 nCoV-19
intracerebral hemorrhage
sinus thrombosis
thrombosis with thrombocytopenia syndrome
vaccination
intracerebral hemorrhage
sinus thrombosis
thrombosis with thrombocytopenia syndrome
ChAdOx1 nCoV-19
vaccination
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Summary:A 48-year-old Japanese man who had no previous medical history received his first dose of the ChAdOx1 nCoV-19 vaccine. Ten days after the vaccine administration, he developed a headache. Laboratory results indicated throm-bocytopenia and DIC. A head CT revealed microbleeding in the left parietal lobe. Contrast-enhanced CT showed thrombus in the left transverse sinus and left sigmoid sinus. A brain MRI demonstrated venous hemorrhagic infarction and subarachnoid hemorrhages in the left parietal lobe, and whole-body enhanced CT also revealed portal vein embolism and renal infarction. He was diagnosed with thrombosis with thrombocytopenia syndrome, and was treated according to the guideline. He has been recovering with the treatments. This is the first reported case of TTS associated with the ChAdOx1 nCoV-19 vaccine in Japan.
ISSN:0009-918X
1882-0654
DOI:10.5692/clinicalneurol.cn-001741