FUNDAMENTAL AND CLINICAL STUDIES OF JOSAMYCIN IN PEDIATRICS FIELD

1) The sensitivity of 89 strains of coagulase positive Staphylococcus aureus, isolated from patients, was studied by means of plate dilution method. Most of test strains was inhibited in 1. 56 mcg/ m l and 3. 12 mcg/ml, and only four strains was showed more than 100 mcg/ml in MIC. 2) When 250 mg of...

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Published inCHEMOTHERAPY Vol. 17; no. 4; pp. 654 - 658
Main Authors FUJII, RYOCHI, ICHIHASHI, HARUO, KONNO, MASATOSHI, UNO, SUSUMU, TAKESHITA, NAONORI, OKADA, KAZUHO, HACHIMORI, KEI, UBUKATA, KIMIKO
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 25.05.1969
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Summary:1) The sensitivity of 89 strains of coagulase positive Staphylococcus aureus, isolated from patients, was studied by means of plate dilution method. Most of test strains was inhibited in 1. 56 mcg/ m l and 3. 12 mcg/ml, and only four strains was showed more than 100 mcg/ml in MIC. 2) When 250 mg of josamycin were administered orally in three children, maximum blood level was 0. 5 mcg/ml (at the 1st hour) in two cases and 3. 60 mcg/ml (at the 4th hour) in o t her one case Urinary recovery rate is reported. 3) Josamycin was administered to 27 patients with acute infections, in 17 of whom the drug was found to be effective.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.17.654