EXPERIMENTAL AND CLINICAL STUDIES ON THIOPHENICOL

• Published in: CHEMOTHERAPY Vol. 15; no. 5; pp. 546 - 548
• Main Authors: AOYAMA, A., MORITA, S., TAKANO, M., TARUMI, A., GOTO, Y., ITO, M.
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1967
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.15.546

Antibacterial activity in vitro of thiophenicol (TP), a new antibiotic, was examined and comparedl with that of chloramphenicol (CP). The blood level and urinary excretion of those two antibiotics after oral administration was determined. Clinically, TP was administered to 19 patients with infectious diseases of the respiratory, billiary or urinary tracts. The results obtained were as follow.: 1) Against 15 standard strains of gram positive or negative bacteria, antibacterial activity of TP in vitro was subordinated to CP. 2) Both TP and CP had maintained approximately same level in the blood after administration, although, TP had higher urinary output. 3) Twelve of nineteen patients received TP administration had apparent susceptability to this antibiotic. As a side effect of TP, gastrointestinal disturbance was observed in few patients. To urinary tract infection, TP was considered to be predominant to CP in this study.