GENERAL PHARMACOLOGICAL EFFECTS OF CARBENICILLIN INDANYL SODIUM

General pharmacological effects of I-CBPC were studied and the following results were obtained. 1. I-CBPC at doses of 1, 000 mg/kg-3, 000 mg/kg (p.o.) had no effects on spontaneous motor activity, motor coordination traction performance, gastrointestinal propulsion, hexobarbital sleeping time and pa...

Full description

Saved in:
Bibliographic Details
Published inCHEMOTHERAPY Vol. 23; no. 2; pp. 583 - 590
Main Authors OTSUKI, ISAO, ISHIKO, JYUNICHI
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 1975
Online AccessGet full text

Cover

More Information
Summary:General pharmacological effects of I-CBPC were studied and the following results were obtained. 1. I-CBPC at doses of 1, 000 mg/kg-3, 000 mg/kg (p.o.) had no effects on spontaneous motor activity, motor coordination traction performance, gastrointestinal propulsion, hexobarbital sleeping time and pain response in mice. 2. There were no effects of I-CBPC on EEG in rabbits, cornea reflex in guinea-pigs, isolated rabbit heart preparations and skeletal muscle preparations in rats. I-CBPC at high concentration showed very weak spasmolytic activity in isolated guinea-pig ileum. 3. I-CBPC, given i. v., caused a fall of blood pressure in the anesthetized dogs, but had no effect on nictitating membrane contractions in the anesthetized cats. 4. Urine excretion was reduced, and diarrhea was also noted in rats treated with I-CBPC at high oral dose.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.23.583