GENERAL PHARMACOLOGICAL EFFECTS OF CARBENICILLIN INDANYL SODIUM
General pharmacological effects of I-CBPC were studied and the following results were obtained. 1. I-CBPC at doses of 1, 000 mg/kg-3, 000 mg/kg (p.o.) had no effects on spontaneous motor activity, motor coordination traction performance, gastrointestinal propulsion, hexobarbital sleeping time and pa...
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Published in | CHEMOTHERAPY Vol. 23; no. 2; pp. 583 - 590 |
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Main Authors | , |
Format | Journal Article |
Language | Japanese |
Published |
Japanese Society of Chemotherapy
1975
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Online Access | Get full text |
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Summary: | General pharmacological effects of I-CBPC were studied and the following results were obtained. 1. I-CBPC at doses of 1, 000 mg/kg-3, 000 mg/kg (p.o.) had no effects on spontaneous motor activity, motor coordination traction performance, gastrointestinal propulsion, hexobarbital sleeping time and pain response in mice. 2. There were no effects of I-CBPC on EEG in rabbits, cornea reflex in guinea-pigs, isolated rabbit heart preparations and skeletal muscle preparations in rats. I-CBPC at high concentration showed very weak spasmolytic activity in isolated guinea-pig ileum. 3. I-CBPC, given i. v., caused a fall of blood pressure in the anesthetized dogs, but had no effect on nictitating membrane contractions in the anesthetized cats. 4. Urine excretion was reduced, and diarrhea was also noted in rats treated with I-CBPC at high oral dose. |
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ISSN: | 0009-3165 1884-5894 |
DOI: | 10.11250/chemotherapy1953.23.583 |