CLINICAL EXPERIENCE WITH SINGLE DOSE OF SULFAMETHOPYRAZINE IN THE TREATMENT OF THE FEMALE ACUTE CYSTITIS

Sulfamethopyrazine is a long-acting sulfa drug which has been synthesized in the Farmitalia Research Laboratory. Three. healthy individuals and 4 in-patients received 2 g of sulfamethopyrazine in a single dose, and blood levels and urinary concentration were subsequently determined using thin layer...

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Published inCHEMOTHERAPY Vol. 20; no. 6; pp. 775 - 780
Main Authors FUKUSHIMA, SHUJI, MATSUOKA, SHUNSUKE, IWAMOTO, TERUAKI
Format Journal Article
LanguageJapanese
Published Japanese Society of Chemotherapy 25.11.1972
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Summary:Sulfamethopyrazine is a long-acting sulfa drug which has been synthesized in the Farmitalia Research Laboratory. Three. healthy individuals and 4 in-patients received 2 g of sulfamethopyrazine in a single dose, and blood levels and urinary concentration were subsequently determined using thin layer cup method. 1. Plasma concentration reaches at a maximum level 4 hours after drug administration and afterwards it falls progressively. 2. Plasma half life was more than 72 hours in the 3 cases among 4 in-patients tested. Thirty-two female patients suffering from acute cystitis were treated with sulfamethopyrazine administered orally in a single 2 g dose. The therapeutic results were very satisfactory, as 71. 9% of the cases treated was cured.
ISSN:0009-3165
1884-5894
DOI:10.11250/chemotherapy1953.20.775