ABSORPTION AND EXCRETION OF INTRAVENOUSLY INJECTED OLEANDOMYCIN IN N ORMAL ADULTS AND PATIENTS WITH IMPAIRED RENAL FUNCTION

• Published in: CHEMOTHERAPY Vol. 16; no. 1; pp. 62 - 68
• Main Authors: TAHARA, MICHIO, MIYAMURA, RYOZO, KAWADA, YUKIMICHI, MIZUTANI, HIDEYUKI, SHIMANO, EIICHIRO, NISHIURA, TUNEO
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Chemotherapy 1968
• ISSN: 0009-3165; 1884-5894
• DOI: 10.11250/chemotherapy1953.16.62

Oleandomycin phosphate (Matromycin) 500 mg was injected intravenously by the drop infusion in just 1 hour to 7 healthy volunteers and 12 patients with to variable extent impaired renal function. Mean serum concentration reached the highest level at 1 hour after the biginning of inject ion in both volunteer group and patient group, it was in the first group 20. 9 ± 6. 1 mcg/ml, and 40. 9± 11. 4 mcg/m1 in the second group. After 9 hours, serum concentration became undetectable level in volunteer group.. Conversely, it was sustained at 2. 5±0. 3 mcg/ml in patient group. Mean urinary concentration in volunteer group was 438±27 0 mcg/ml, and 298 ± 97 mcg/ml in patient, group in first 1 hour, and then 61 ± 22 mcg/ml and 40± 11 mcg/ml in the urine collecting from 6th to 9th hour respectively. Average 9 hours urinary recovery rate was 24. 0± 5. 0% in volunteers and 1 3. 9 ± 3. 1% in patients. Oleandomy cin clearance value was 43. 4 ± 11. 5 ml/min. in volunteers, but in patients it was reduced depending upon the severity of impairement of renal function. The administration of Probenecid made the oleandomy cin serum level lowered and its clearance value notably elevated. This means that oleandomycin was markedly reabsorbed at renal tubulus, and Probenecid disturbed the reabsorption. The correlation of o leandomycin clearance values with values of renal function tests was discussed. The most excellent correlation was obserbed with FISHBERG's concentration test, especially its maximall urine osmolatities. PSP test '(15 minutes values), urine specific gravidites and creatinine clearance values had also good correlation.