Mechanism of the microbicidal (detoxication) effect by the myeloperoxidase-H2O2-halide system V. Oxidation of benzylpenicillin

Benzylpenicillin, an antibiotic was oxidized by myeloperoxidase, hydrogen peroxide and chloride, and particularly in an acidic solution (pH 4.5 to 5.0). Until about 20 mM chloride, the rate of oxidation reaction increased in propotion to the concentration of chloride, although with a higher concentr...

Full description

Saved in:
Bibliographic Details
Published inJapanese Journal of Oral Biology Vol. 23; no. 3; pp. 498 - 502
Main Authors Odajima, Takeshi, Sato, Naoko, Onishi, Mihoko
Format Journal Article
LanguageEnglish
Japanese
Published Japanese Association for Oral Biology 20.09.1981
Subjects
benzylpenicillin
myeloperoxidase
Online AccessGet full text

Cover

More Information
Summary:Benzylpenicillin, an antibiotic was oxidized by myeloperoxidase, hydrogen peroxide and chloride, and particularly in an acidic solution (pH 4.5 to 5.0). Until about 20 mM chloride, the rate of oxidation reaction increased in propotion to the concentration of chloride, although with a higher concentration, a rapid decrease was observed. And, one product was detected by using high pressure reverse phase partition chromatography. The product had a lower polarity, compared with benzylpenicillin.
ISSN:0385-0137
DOI:10.2330/joralbiosci1965.23.498