Studies on the Mechanism of Antimicrobial Action of Dehydroacetic Acid (DHA) part 1 (1) On the Mode of Growth Inhibition of Dehydroacetic Acid and the Influence of Medium pH on its Activity (2) On the Elimination of Growth Inhibitory Action by Addition of Thiol-compound or Metal-ion

• Published in: Nippon Nōgeikagaku Kaishi Vol. 28; no. 9; pp. 727 - 732
• Main Authors: NOMOTO, Masao, NAMIKI, Mitsuo, NAMIKI, Kazuko
• Format: Journal Article
• Language: Japanese
• Published: Japan Society for Bioscience, Biotechnology, and Agrochemistry 1954
• ISSN: 0002-1407; 1883-6844
• DOI: 10.1271/nogeikagaku1924.28.727

Growth inhibitory actions of both DHA (Dehydroacetic acid) and DAC (Dehyoroacetocarooxylic acid) against several microörganisms were studied by the method of photoelectro-turbidi-metry. The results were as follows: (1) Both DHA and DAC inhibited the growth of microörganisms in the logarithmic and stationary-phase of their multiplications. (2) DHA inhibited the growth of yeast and Acetobacter, but its antimicrobial activities disappeared against Lactobacilli. On the contrary, DAC inhibited the growth of Lactobacilli. but became harmless against yeast and Acetobacter. (3) The antimicrobial activities of both DHA and DAC were influenced by medium-pH, i.e. they strongly appeared in acidic-side of pH of medium, and became weaker in alkalineside. The effects of SH-compounds (cysteine and thioglycolic acid) or metal-ions on the growth inhibitory actions of DHA and DAC were also studied. As a result, there was no eliminatng action by addition of SH-compounds or metal-ions.