The study on α-fetoprotein (V) Studies on suppressive effects of anti-AFP serum on rat hepatoma-Immunohistochemical investigations
It was reported that horse anti-AFP serum had a suppressive effect on 3'-Me-DAB rat hepatoma. In order to clarify the mechanism of the effect, the correlation between tissue AFP and administered anti-AFP was immunohistochemically investigated. The result was characterized by a decrease in the n...
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| Published in | Kanzo Vol. 21; no. 12; pp. 1637 - 1646 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
25.12.1980
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| Subjects | |
| Online Access | Get full text |
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| Summary: | It was reported that horse anti-AFP serum had a suppressive effect on 3'-Me-DAB rat hepatoma. In order to clarify the mechanism of the effect, the correlation between tissue AFP and administered anti-AFP was immunohistochemically investigated. The result was characterized by a decrease in the number of AFP positive cells, and the proven localization of horse immunoglobulin in the liver of rats treated with anti-AFP specific antibody. This fact indicates the possibility of AFP-anti AFP immunoreaction at the site of AFP producing cells, and it is suggested that this Ag-Ab reaction may cause the suppressive effect on 3'-Me-DAB rat hepatoma. |
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| ISSN: | 0451-4203 1881-3593 |
| DOI: | 10.2957/kanzo.21.1637 |