EXPERIMENTAL STUDIES ON DIFFUSION OF GENTAMICIN INTO BODY FLUIDS

For the purpose of measuring concentrations of gentamicin (GM) into body fluids (pancreatic juice, abdominal cavity, and bile) after intramuscular injection, the authors conducted experiments using adult mongrel dogs with following results. 1) The highest concentration in pancreatic juice was observ...

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Published inJapanese journal of antibiotics Vol. 29; no. 12; pp. 1035 - 1041
Main Authors RI, UGEN, MIURA, JUN-ICHI, YOTSUYA, TOSHIRO, TAKAYAMA, HIROO, ISHII, JUN-ICHI
Format Journal Article
LanguageJapanese
Published Japan Japan Antibiotics Research Association 01.12.1976
Subjects
Adolescent
Adult
Animals
Ascitic Fluid - analysis
Bile - analysis
Body Fluids - analysis
Child
Dogs
Female
Gentamicins - adverse effects
Gentamicins - metabolism
Gentamicins - therapeutic use
Humans
Injections, Intramuscular
Male
Middle Aged
Pancreatic Juice - analysis
Surgical Wound Infection - drug therapy
Urinary Tract Infections - drug therapy
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Summary:For the purpose of measuring concentrations of gentamicin (GM) into body fluids (pancreatic juice, abdominal cavity, and bile) after intramuscular injection, the authors conducted experiments using adult mongrel dogs with following results. 1) The highest concentration in pancreatic juice was observed 1-1.5 hours after single intramuscular administration of 4mg/kg. The highest concentration was 51.3% of that in blood. 2) The highest concentration in bile was observed 30 minutes -1 hour after single intramuscular administration of GM. The concentration was about 50% of that in blood. 3) The diffusion of GM into the abdominal cavity was good after single intramuscular administration. 4) The rate of urinary excretion was high as is generally known.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.29.1035