CLINICAL STUDIES ON TOBRAMYCIN USING INTRAVENOUS DRIP INFUSION

• Published in: Japanese journal of antibiotics Vol. 34; no. 9; pp. 1255 - 1262
• Main Authors: SAITO, AKIRA, KIKUIRI, TSUYOSHI, TOMIZAWA, MASUMI, UJIIE, AKIRA, KINOSHITA, YOSHIO
• Format: Journal Article
• Language: Japanese
• Published: Japan Japan Antibiotics Research Association 01.09.1981
• Subjects: Adult; Aged; Anti-Bacterial Agents - administration & dosage; Bacterial Infections - drug therapy; Drug Evaluation; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Tobramycin - administration & dosage; Tobramycin - adverse effects; Tobramycin - blood
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.34.1255

Clinical studies and serum levels on tobramycin (TOB) using intravenous drip infusion were carried out and the following results were obtained. 1. Clinical results Nineteen patients with various infections including 11 respiratory tract infections, 7 urinary tract infections and a wound infection were treated with TOB 20-60mg b. i. d. and t. i. d. by intravenous drip infusion for 1 hour during 4 to 16 days.Clinical effects were excellent in 10 cases, good in 4 cases, fair in 2 cases and failure in 3 cases. It was 73.7% of the efficacy rate of the drug. Side effects were observed in 2 cases of oliguria and increase in BUN, S-creatinine and S-potassium. 2. Serum levels of TOB Serum levels of TOB administrated 30 or 60mg intravenous drip infusion for 1 hour were measured in first and final administration of 8 patients.The peak serum levels were 3.1-5.0μg/ml at the end of infusion in first 60mg administration of the drug,.and 3.8-5.3μg/ml in final 60mg administration of the drug.