Histoimmunological Studies on the Mucous Membrane of Paranasal Sinuses Part 2. The Effects of Vitamin C on the Mucous Membrane of Paranasal Sinuses

• Published in: Japanese Journal of National Medical Services Vol. 18; no. 10; pp. 706 - 712
• Main Authors: TANABE, Shizuo, FUJITANA, Kojiro, TABUCHI, Yutaka, NAKAMURA, Masahide
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of National Medical Services 20.10.1964
• ISSN: 0021-1699; 1884-8729
• DOI: 10.11261/iryo1946.18.706

This experiment was made to investigate the effects of vitamin C on the mucous membrane and the secretion of parasinuses, particularly of maxillar sinus, of the cases of chronic sinusitis which developed within recent 3 years by means of oral administration of daily dosis of 1, 000mg of vitamin C with together an antihemorrhagic agent for one to six weeks prior to surgery. The results obtained are as follows: 1) Administration of vitamin C for 1 week prior to surgery: No effects were observed on the content of vitamin C in the mucous membrane and the microorganisms in the secretion of paranasal sinuses. 2) Administration for 2 weeks: Vitamin C was appeared slightly in the connective, epithelial and glandular tissue. The number and kind of microorganisms in the secretion of paranasal sinuses began to decrease and the some of the membranes became immune from that microorganisms. 3) Administration for 3 weeks: The increase was observed in the content of vitamin C as well as the rising in the titer of immunity of the connective tissue. 4) Administration for 4 weeks: The content of the vitamin C was markedly increased and significant reduction of the microorganisms was observed. 5) These effects of vitamin C have not any relationship with the pathological type of the mucous membrane of paranasal sinuses.