Studies on the Development of Novel Antileprous Chemotherapeutics Using Nude Mice With Special Reference to a New Quinolone Carboxylic Acid, AT-4140

In order to develop a novel drug for antileprosy chemotherapy, the inhibitory effects of three synthesized compounds, a supplied antituberculous one and three quinolone carboxylic acids were examined on the growth of leprosy bacilli inoculated into the footpads of nude mice. Amongst them, a new quin...

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Bibliographic Details
Published inJapanese journal of leprosy Vol. 58; no. 4; pp. 250 - 258
Main Authors TSUTSUMI, Sadae, GIDOH, Masaichi
Format Journal Article
LanguageJapanese
Published Japanese Leprosy Association 30.12.1989
Subjects
a novel quinolone carboxylic acid
antileprous chemotherapeutics
AT-4140
footpad swelling
nude mice
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Summary:In order to develop a novel drug for antileprosy chemotherapy, the inhibitory effects of three synthesized compounds, a supplied antituberculous one and three quinolone carboxylic acids were examined on the growth of leprosy bacilli inoculated into the footpads of nude mice. Amongst them, a new quinolone carboxylic acid, AT-4140 whose chemical strurture was 5-amino-1-cyclopropyl-6, 8-difluoro-1, 4-dihydro-7-( cis-3, 5-dimethyl-1-piperazinyl )-4-oxoquinoline-3-carboxylic acid strongly inhibited the growth of leprosy bacilli at doses of 15 and 30mg/kg. Whereas, the efffct of Ofloxacin used as a positive control was limited at the same doses.
ISSN:0386-3980
2185-1360
DOI:10.5025/hansen1977.58.250