CLINICAL EFFICACY OF CEFTRIAXONE WHEN ADMINISTERED ONCE DAILY TO RESPIRATORY TRACT INFECTIONS IN PATIENTS WITH ADVANCED AGES

Ceftriaxone (CTRX), a new third generation cephalosporine, was investigated upon once daily administration for its clinical efficacy and safety on respiratory tract infections in patients with advanced ages.The results are summarized as follows: 1. Clinical responses to CTRX of 48 cases of advanced...

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Published inJapanese journal of antibiotics Vol. 45; no. 6; pp. 681 - 686
Main Authors TAKIZAWA, SHIGEO, YANASE, KENJI, HASHIZUME, IKKO, KASAMATSU, NORIO, TACHIBANA, AKIO, OGISU, NOBUO, OKAZAWA, MITSUSHI
Format Journal Article
LanguageJapanese
Published Japan Japan Antibiotics Research Association 01.06.1992
Subjects
Aged
Aged, 80 and over
Ceftriaxone - administration & dosage
Ceftriaxone - adverse effects
Ceftriaxone - blood
Exanthema - chemically induced
Female
Humans
Male
Respiratory Tract Infections - drug therapy
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Summary:Ceftriaxone (CTRX), a new third generation cephalosporine, was investigated upon once daily administration for its clinical efficacy and safety on respiratory tract infections in patients with advanced ages.The results are summarized as follows: 1. Clinical responses to CTRX of 48 cases of advanced age patients with respiratory tract infections were good with an efficacy rate of 89.6%. 2. Adverse reactions to CTRX were mainly exanthema in 7 cases (14.6%). 3. Serum levels of CTRX were determined in 4 cases after intravenous drip infusion of 2g CTRX.Serum levels were analyzed by one-compartment model.There was no evidence of accumulation of CTRX in the patients with advanced ages.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.45.681