CLINICAL EVALUATION OF FLUCONAZOLE IN THE CASE OF DEEP MYCOSIS ASSOCIATED WITH LEUKEMIA

• Published in: Japanese journal of antibiotics Vol. 42; no. 1; pp. 117 - 126
• Main Authors: MARUTA, ATSUO, MATSUZAKI, MICHIO, FUKAWA, HITOSHI, KODAMA, FUMIO
• Format: Journal Article
• Language: Japanese
• Published: Japan Japan Antibiotics Research Association 01.01.1989
• Subjects: Acute Disease; Adolescent; Adult; Aged; Antifungal Agents - administration & dosage; Antifungal Agents - blood; Antifungal Agents - therapeutic use; Candidiasis - blood; Candidiasis - drug therapy; Candidiasis - etiology; Drug Evaluation; Drug Tolerance; Female; Fluconazole; Humans; Injections, Intravenous; Leukemia - complications; Lung Diseases, Fungal - drug therapy; Lung Diseases, Fungal - etiology; Male; Middle Aged; Triazoles - administration & dosage; Triazoles - blood; Triazoles - therapeutic use
• ISSN: 0368-2781; 2186-5477
• DOI: 10.11553/antibiotics1968b.42.117

The clinical efficacy of fluconazole at doses of 100-400mg daily given intravenously in the treatment of 6 cases of deep mycosis complicated with leukemia was evaluated. Types of leukemia as underlying disease were acute lymphatic leukemia in 4 patients (included post bone marrow transplantation in 2 patients), acute myelocytic leukemia in 1 and acute myelomonocytic leukemia (AMMoL) in 1. Causative fungi were Candida in all patients. Diagnoses established were pulmonary or bronchial candidiasis in 3 patients, candiduria in 2 and suspected candidemia accompanied with stomatitis in 1. A patient with candiduria died from AMMoL thus the evaluation of efficacy was made with 5 patients. Overall clinical efficacies were judged to be good in 3 cases of pulmonary or bronchial candidiasis and in 1 case of suspected candidemia accompanied with stomatitis and excellent in 1 case of candiduria with an efficacy rate of 100%. No side effect, either subjective or objective, was reported with any patient. In clinical laboratory tests, elevations of serum transaminase and Al-P were observed in 2 patients and a rise of S-Cr. in 1, but all these abnormalities were judged to be related to the drugs for leukemia treatment.