Evaluation Indices of Bile Acid Dynamics by Mathematical Modeling

• Published in: Transactions of Japanese Society for Medical and Biological Engineering Vol. 41; no. 4; pp. 282 - 287
• Main Authors: KATAYAMA, Toshiro, SATO, Tetsuo, MINATO, Kotaro
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society for Medical and Biological Engineering 10.12.2003
• ISSN: 1347-443X; 1881-4379
• DOI: 10.11239/jsmbe2002.41.282

This paper proposes two indices in order to quantitatively evaluate the physiological function of the bile acid dynamics of a supplement. We describe the mathematical model for an enterohepatic circulation mechanism of bile acid by conation of the bile acid endurance test. By simulating drifting time course for loading bile acid in the serum using linear differential equations, we extracted the bile acid absorption rate from intestinum tenue and the bile acid uptake rate from portal system in liver as the two indices of the serum bile acid level. We utilized powder tablets of layer as an example of supplements and conducted bile acid endurance tests for 1 wk before and after taking the tablets using six subjects whose serum cholesterol rose an inconsiderable amount. We reviewed the utility of these two indices through detailed experiments. There is a significant difference in the indices between before and after taking the supplement. In addition, after taking tablets, the serum total cholesterol level falls to a clinical normal level. This experiment shows that the indices, which are estimated from simulation of a bile acid endurance test, are useful to quantitatively evaluate the lipid drifting effects of supplements.