Occlusion of the middle cerebral artery with transorbital approach in cat An experimental model of focal cerebral ischemia
Occlusion of a middle cerebral artery (MCA) with the transorbital approach produces a satisfactory experimental model of focal cerebral ischemia and this method has found widespread application in cats and primates. With the transorbital approach, the MCA is exposed easily through the enlarged optic...
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| Published in | Japanese Journal of Stroke Vol. 9; no. 3; pp. 177 - 192 |
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| Main Author | |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Stroke Society
25.06.1987
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| Online Access | Get full text |
| ISSN | 0912-0726 1883-1923 |
| DOI | 10.3995/jstroke.9.177 |
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| Summary: | Occlusion of a middle cerebral artery (MCA) with the transorbital approach produces a satisfactory experimental model of focal cerebral ischemia and this method has found widespread application in cats and primates. With the transorbital approach, the MCA is exposed easily through the enlarged optic foramen, while the integrity of the cranium is maintained and disturbance or manipulation of the brain is avoided. Delayed closure with an implanted device placed around the MCA allows for extended physiological observation of an animal suffering from ischemic cerebral damage. Since the first description of this model in cat by O'Brien and Waltz in 1973, a considerable amount of research with this model has been reported. In the present paper, literature dealing with transorbital MCA occlusion in cat as an experimental model of focal cerebral ischemia is reviewed, and the usefulness and shortcomings of this model are discussed. |
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| ISSN: | 0912-0726 1883-1923 |
| DOI: | 10.3995/jstroke.9.177 |