Ｈｙｂｒｉｄ　Ａｒｔｉｆｉｃｉａｌ　Ｌｉｖｅｒの研究　　遊離肝細胞封入ＰＡＮ‐ＨＦモジュールの代謝維持能

• Published in: Jinko Zoki Vol. 10; no. 2; pp. 541 - 545
• Main Authors: KASAI S., OIKAWA I., HAYASHI K., OHNO M., ASAKAWA H., YAMAMOTO T., SEKIGUCHI S., MITO M.
• Format: Journal Article
• Language: Japanese
• Published: 一般社団法人 日本人工臓器学会 1981; JAPANESE SOCIETY FOR ARTIFICIAL ORGANS
• Subjects: hybrid artificial liver; isolated hepatocytes; metabolic activity; polyacrylonitrile hollow fiber
• ISSN: 0300-0818; 1883-6097
• DOI: 10.11392/jsao1972.10.541

The present experiment was disigned to evaluate metabolic abilities of a prototype for a hybrid artificial liver. The module utilizing polyacrylonitrile hollow fiber (Asahi Medical Co., Tokyo.) was employed for the prototype. The hepatocytes which were obtained from dog were sealed into the perfusate site of the module. The metabolic activity of the module was examined by an invitro perfusion technique. The following results were obtained that oxygen was cunsumed, ammonia decreased remarkably, urea-N and glucose increased slightly, and some amino asids changed in each individual range. These support the usefulness of the module for developing a hybrid artificial liver.