A Case of Pulmonary Malignant Fibrous Histiocytoma in which Cytokines Exihibited High Value by Subculture

• Published in: The Japanese journal of thoracic diseases Vol. 31; no. 4; pp. 523 - 529
• Main Authors: Kato, Nobuhide, Sakuragawa, Hiroshi, Yamazaki, Shirou, Komatsu, Hisashi, Ishikawa, Fumio, Okada, Yayoi, Kakiuchi, Terutaka, Sasamoto, Shuuichi
• Format: Journal Article
• Language: English; Japanese
• Published: The Japanese Respiratory Society 25.04.1993
• Subjects: cytokines; Ferittin; G-CSF; Interleukin-6; Pulmonary Malignant Fibrous Histiocytoma
• ISSN: 0301-1542; 1883-471X
• DOI: 10.11389/jjrs1963.31.523

A case of pulmonary malignant fibrous histiocytoma (PMFH) was experienced, and the tumor was subcultured in nude mice. Tumor cells were resected and cultured in medium containing RPMI 1640 and 10% FCS. As a result, in both the nude mice and in the cytokines, as supernatant in the tumorous cells, cultured using ELISA method or RIA method. IL-1α, β, TNF-α, GM-CSF, and in particular IL-6 and G-CSF, exhibited markedly raised values. Clinically, the leukocyte and platelet counts on admission showed markedly elevated values of 27, 500/mm3 and 48.3×104/mm3, respectively, and the erythrocyte sedimentation rate was increased of 67mm in 1 hour. These findings corresponded to the physiological findings of elevated IL-6 and G-CSF levels. We have experienced two further patients with PMFH, in whom serum levels of IL-6 and G-CSF were markedly elevated. Some reports have been published on cytokine-generating tumors, but there is no report about cytokine generation in PMFH. We report this patient's very interesting clinical course, together with elevation of cytokine generation.