Studies on the immune response in patients with chronic renal failure 4. Inhibitory effect of blastoid transformation of lymphocytes by methylguanidine in vitro

The inhibitory effect of methylguanidine (MG) on PHA-induced blastoid transformation of lymphocytes from normal subjects was examined in vitro. MG inhibited the response of lymphocytes at concentrations higher than 12.5μg/ml. This inhibitory effect of MG showed dose dependency. It was previously rep...

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Bibliographic Details
Published inJournal of Japanese Society for Dialysis Therapy Vol. 16; no. 4; pp. 231 - 233
Main Author Morikawa, Yoji
Format Journal Article
LanguageJapanese
Published The Japanese Society for Dialysis Therapy 31.08.1983
Subjects
chronic renal failure
guanidino compounds
immunity
methylguanidine
uremic toxin
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ISSN0288-7045
1884-6203
DOI10.4009/jsdt1968.16.231

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Summary:The inhibitory effect of methylguanidine (MG) on PHA-induced blastoid transformation of lymphocytes from normal subjects was examined in vitro. MG inhibited the response of lymphocytes at concentrations higher than 12.5μg/ml. This inhibitory effect of MG showed dose dependency. It was previously reported that the stimulation index of PHA-induced blastoid transformation of lymphocytes in whole blood culture and serum concentration of MG for the patients with chronic renal failure (CRF) were inversely correlated. From this previous report and this result in vitro, MG can be considered to be one of the inhibitory substances against the cellular immunity in plasma of CRF patients.
ISSN:0288-7045
1884-6203
DOI:10.4009/jsdt1968.16.231