A case of recurrent Clostridium difficile infection with type 2 diabetes mellitus indicating the usefulness of metformin hydrochloride

A 76-year-old woman undergoing insulin treatment for type 2 diabetes mellitus at our hospital was diagnosed with Clostridium difficile infection (CDI). She was treated with metronidazole, vancomycin hydrochloride, and fidaxomicin. Metformin hydrochloride in combination with fidaxomicin was administe...

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Bibliographic Details
Published inNippon Shōkakibyō Gakkai zasshi Vol. 120; no. 2; p. 162
Main Authors Obata, Kazuhiko, Yamashita, Shigeo
Format Journal Article
LanguageJapanese
Published Japan 2023
Subjects
Aged
Anti-Bacterial Agents - therapeutic use
Clostridioides difficile
Clostridium Infections - complications
Clostridium Infections - drug therapy
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Female
Fidaxomicin - therapeutic use
Humans
Metformin - therapeutic use
Metronidazole - therapeutic use
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Summary:A 76-year-old woman undergoing insulin treatment for type 2 diabetes mellitus at our hospital was diagnosed with Clostridium difficile infection (CDI). She was treated with metronidazole, vancomycin hydrochloride, and fidaxomicin. Metformin hydrochloride in combination with fidaxomicin was administered to control the exacerbated symptoms. The diarrhea disappeared two days later, and colonoscopy confirmed the resolution of pseudomembranes eight days later. Till approximately two years after discharge, no recurrence was observed. Here metformin hydrochloride was suggested to be useful for the treatment of recurrent CDI with type 2 diabetes mellitus.
ISSN:0446-6586
DOI:10.11405/nisshoshi.120.162