Multiple Digestive Enzymes Activity and Inactivation of Digestive Enzymes
The activity of α-amylase, glucoamylase, protease, lipase and cellulase contained in such commercial multiple digestive enzyme preparations as Aczym, Excelase, Politose and Toughmac-E capsule was determined. These digestive enzymes were immersed in citric acid solution with a pH of 2.0 for 5 minutes...
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| Published in | Japanese Journal of Hospital Pharmacy Vol. 4; no. 1; pp. 31 - 34 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
Japanese Society of Pharmaceutical Health Care and Sciences
1978
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| Online Access | Get full text |
| ISSN | 0389-9098 2185-9477 |
| DOI | 10.5649/jjphcs1975.4.31 |
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| Abstract | The activity of α-amylase, glucoamylase, protease, lipase and cellulase contained in such commercial multiple digestive enzyme preparations as Aczym, Excelase, Politose and Toughmac-E capsule was determined. These digestive enzymes were immersed in citric acid solution with a pH of 2.0 for 5 minutes and the loss rate of enzyme activity due to acidic environment was determined. Each digestive enzyme had characteristic activity against each substrate. However, all the four preparations showed a 100% loss in glucoamylase activity, while the loss rate of α-amylase, protease, lipase and cellulase ranged from 30 to 76%. Therefore, multiple digestive enzyme preparations should be coated with materials suitable for each enzyme contained in view of changing pH in digestive tract. |
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| AbstractList | The activity of α-amylase, glucoamylase, protease, lipase and cellulase contained in such commercial multiple digestive enzyme preparations as Aczym, Excelase, Politose and Toughmac-E capsule was determined. These digestive enzymes were immersed in citric acid solution with a pH of 2.0 for 5 minutes and the loss rate of enzyme activity due to acidic environment was determined. Each digestive enzyme had characteristic activity against each substrate. However, all the four preparations showed a 100% loss in glucoamylase activity, while the loss rate of α-amylase, protease, lipase and cellulase ranged from 30 to 76%. Therefore, multiple digestive enzyme preparations should be coated with materials suitable for each enzyme contained in view of changing pH in digestive tract. |
| Author | Seki, Yoko Fukuchi, Hiroshi Kawakita, Yurie Shintani, Hiromichi Yoshida, Minoru Ikeda, Hiroaki |
| Author_xml | – sequence: 1 fullname: Fukuchi, Hiroshi organization: Department of Pharmaceutical Services, Hiroshima University Hospital – sequence: 1 fullname: Seki, Yoko organization: Department of Pharmaceutical Services, Hiroshima University Hospital – sequence: 1 fullname: Yoshida, Minoru organization: Department of Pharmaceutical Services, Hiroshima University Hospital – sequence: 1 fullname: Shintani, Hiromichi organization: Department of Pharmaceutical Services, Hiroshima University Hospital – sequence: 1 fullname: Ikeda, Hiroaki organization: Department of Pharmaceutical Services, Hiroshima University Hospital – sequence: 1 fullname: Kawakita, Yurie organization: Department of Pharmaceutical Services, Hiroshima University Hospital |
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| DOI | 10.5649/jjphcs1975.4.31 |
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| References | 1) 岡崎寛蔵, 北村允夫, 鈴木進, 中郡英次: 薬剤学, 16, 12 (1956). 5) 永瀬一郎, 藤代とし, 岡本尚子: 病院薬学, 2, 256 (1977). 14) J. B. Sumner: J. Biol. Chem., 65, 393 (1925). 8) M. Somogyi: J. Biol. Chem., 160, 61 (1945). 2) 岡崎寛蔵, 大島壮一, 長沢潤一, 白井トシ子, 小島波子: 薬剤学, 16, 21 (1956). 13) J. B. Sumner: J. Biol. Chem., 47, 5 (1921). 11) 江上不二夫: 標準生化学実験, 207 (1953). 4) 杉浦衛, 小木曽太郎: 薬剤学, 28, 247 (1968). 10) M. L. Anson: J. Gen. Physiol., 22, 79 (1939). 12) 山田浩一, 町田晴夫: 農芸化学, 36, 858 (1962). 3) 岡崎寛蔵, 片岡秀雄: 薬剤学, 24, 68 (1964). 9) N. Nelson: J. Biol. Chem., 153, 375 (1944). 6) 赤堀四郎: 酵素研究法, 2,108 (1956). 7) R. M. McCready and W. Z. Hassid: J. Am. Chem. Soc., 65, 1154 (1943). |
| References_xml | – reference: 12) 山田浩一, 町田晴夫: 農芸化学, 36, 858 (1962). – reference: 14) J. B. Sumner: J. Biol. Chem., 65, 393 (1925). – reference: 6) 赤堀四郎: 酵素研究法, 2,108 (1956). – reference: 10) M. L. Anson: J. Gen. Physiol., 22, 79 (1939). – reference: 8) M. Somogyi: J. Biol. Chem., 160, 61 (1945). – reference: 4) 杉浦衛, 小木曽太郎: 薬剤学, 28, 247 (1968). – reference: 11) 江上不二夫: 標準生化学実験, 207 (1953). – reference: 13) J. B. Sumner: J. Biol. Chem., 47, 5 (1921). – reference: 7) R. M. McCready and W. Z. Hassid: J. Am. Chem. Soc., 65, 1154 (1943). – reference: 5) 永瀬一郎, 藤代とし, 岡本尚子: 病院薬学, 2, 256 (1977). – reference: 9) N. Nelson: J. Biol. Chem., 153, 375 (1944). – reference: 1) 岡崎寛蔵, 北村允夫, 鈴木進, 中郡英次: 薬剤学, 16, 12 (1956). – reference: 2) 岡崎寛蔵, 大島壮一, 長沢潤一, 白井トシ子, 小島波子: 薬剤学, 16, 21 (1956). – reference: 3) 岡崎寛蔵, 片岡秀雄: 薬剤学, 24, 68 (1964). |
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| Subtitle | Activity and Inactivation of Digestive Enzymes |
| Title | Multiple Digestive Enzymes |
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