Multiple Digestive Enzymes Activity and Inactivation of Digestive Enzymes

• Published in: Japanese Journal of Hospital Pharmacy Vol. 4; no. 1; pp. 31 - 34
• Main Authors: Fukuchi, Hiroshi, Seki, Yoko, Yoshida, Minoru, Shintani, Hiromichi, Ikeda, Hiroaki, Kawakita, Yurie
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society of Pharmaceutical Health Care and Sciences 1978
• ISSN: 0389-9098; 2185-9477
• DOI: 10.5649/jjphcs1975.4.31

The activity of α-amylase, glucoamylase, protease, lipase and cellulase contained in such commercial multiple digestive enzyme preparations as Aczym, Excelase, Politose and Toughmac-E capsule was determined. These digestive enzymes were immersed in citric acid solution with a pH of 2.0 for 5 minutes and the loss rate of enzyme activity due to acidic environment was determined. Each digestive enzyme had characteristic activity against each substrate. However, all the four preparations showed a 100% loss in glucoamylase activity, while the loss rate of α-amylase, protease, lipase and cellulase ranged from 30 to 76%. Therefore, multiple digestive enzyme preparations should be coated with materials suitable for each enzyme contained in view of changing pH in digestive tract.