Stimulated production of active oxygen with anti-microsome antibody positive sera in Basedow's disease

To evaluate pathophysiological significance of anti-microsome antibody positive sera in Basedow's disease, we have examined the production of opsonized zymosan stimulated active oxygens in neutrophils and the chemotaxis stimulated by f-methyonylleucyl-phenylalanine. O-2 significantly increased...

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Bibliographic Details
Published inEnsho Vol. 8; no. 2; pp. 137 - 139
Main Authors Yamashiro, Yuki, Baba, Shigeaki, Niwa, Yukie, Morimoto, Yasuo, Taniguchi, Hiroshi, Mogi, Takateru, Ogura, Hajime
Format Journal Article
LanguageJapanese
Published The Japanese Society of Inflammation and Regeneration 01.03.1988
Subjects
active oxygens
Basedow's disease
chemotaxis
microsome antibody
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Summary:To evaluate pathophysiological significance of anti-microsome antibody positive sera in Basedow's disease, we have examined the production of opsonized zymosan stimulated active oxygens in neutrophils and the chemotaxis stimulated by f-methyonylleucyl-phenylalanine. O-2 significantly increased with sera of Basedow's disease as compared with those of healthy subjects. However OH⋅ production and chemotaxis have not significantly changed. Productive-stimulating factors are, therefore, suggested to be present in the sera of Basedow's disease. The association of the factors with hyperthyroidism was discussed.
ISSN:0389-4290
1884-4006
DOI:10.2492/jsir1981.8.137