Idiotype analysis and immune response with use of anti-idiotypic monoclonal antibody to anti-CEA antibody

Anti-idiotypic monoclonal antibodies(MoAbs) were prepared against anti-CEA monoclonal anti-body 5B3 which reacted with the carbohydrate moiety on CEA. Anti-idiotypic MoAbs recognized the private idiotype on MoAb 5B3. Idiotype mapping of MoAb 5B3 showed that there might be at least three idiotopes on...

Full description

Saved in:
Bibliographic Details
Published inDrug Delivery System Vol. 3; no. 3; pp. 399 - 404
Main Authors Tsujisaki, Masayuki, Tokuchi, Shigeru, Hishikawa, Noriyuki, Ono, Akihiro, Imai, Kohzoh, Yachi, Akira
Format Journal Article
LanguageJapanese
Published THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM 01.10.1988
Subjects
anti-idiotypic antibody
cancer therapy
carcinoembryonic antigen
idiotype mapping
monoclonal antibody
Online AccessGet full text

Cover

More Information
Summary:Anti-idiotypic monoclonal antibodies(MoAbs) were prepared against anti-CEA monoclonal anti-body 5B3 which reacted with the carbohydrate moiety on CEA. Anti-idiotypic MoAbs recognized the private idiotype on MoAb 5B3. Idiotype mapping of MoAb 5B3 showed that there might be at least three idiotopes on the combining site of it. Three different anti-idiotypic MoAbs could induce anti-anti-idiotypic antibodies specific to immunizing anti-idiotypic MoAb respectively. Two anti-anti-idiotypic antibodies out of three might have the same reactivity as that of MoAb 5B3 to CEA. The results suggest that an anti-idiotypic antibody bearing internal image of tumor associated antigen may induce the anti-anti-idiotypic antibodies specific to tumor associated antigen and it may be useful for cancer therapy.
ISSN:0913-5006
1881-2732
DOI:10.2745/dds.3.399