Diminished expression of CD5 and/or CD7 surface antigens as the first clue of diagnosis for monoclonal T lymphocytosis

The significance of precursor status for mature T-cell neoplasms has not been elucidated. Diagnosis of T-cell neoplasms is often challenging and sometimes overlooked when leukocytosis is not evident and neoplastic cell morphology is hardly distinguishable. Here, we report two cases of monoclonal T l...

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Bibliographic Details
Published inRinshō ketsueki Vol. 53; no. 8; p. 785
Main Authors Kawano, Hiroki, Minagawa, Kentaro, Wakahashi, Kanako, Kawano, Yuko, Sada, Akiko, Matsui, Toshimitsu, Katayama, Yoshio
Format Journal Article
LanguageJapanese
Published Japan 01.08.2012
Subjects
Aged
Biomarkers - blood
CD5 Antigens - blood
Female
Flow Cytometry
Humans
Lymphocytosis - diagnosis
Lymphocytosis - immunology
Male
Middle Aged
Nerve Tissue Proteins - blood
T-Lymphocytes - immunology
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Summary:The significance of precursor status for mature T-cell neoplasms has not been elucidated. Diagnosis of T-cell neoplasms is often challenging and sometimes overlooked when leukocytosis is not evident and neoplastic cell morphology is hardly distinguishable. Here, we report two cases of monoclonal T lymphocytosis (MTL) without evident lymphocytosis and lymphadenopathies that show slightly diminished CD5 and/or CD7 surface antigens as the first clue of diagnosis. Recently, some reports have demonstrated the possibility that monoclonal lymphocytosis precedes leukemia/lymphoma. Although its clinical significance is unknown, flow cytometric analysis of peripheral blood is useful for detection of occult MTL and careful follow-up is required.
ISSN:0485-1439
DOI:10.11406/rinketsu.53.785