Classic Hodgkin lymphoma developing early after treatment of follicular lymphoma

There are few reports of a patient presenting with combined follicular lymphoma (FL) and classical Hodgkin lymphoma (cHL). A 37-year-old Japanese man was diagnosed with FL with generalized lymphadenopathy and treated with R-CHOP. Four months later, he presented with fever, elevated lactic acid dehyd...

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Published inRinshō ketsueki Vol. 61; no. 1; p. 39
Main Authors Ueda, Norihiro, Hashimoto, Ken, Yamazoe, Yumi, Adachi, Yoshiya, Kihara, Rika, Kuwabara, Kyouko, Fujino, Masahiko, Watamoto, Koichi
Format Journal Article
LanguageJapanese
Published Japan 2020
Subjects
Adult
Antineoplastic Combined Chemotherapy Protocols
Hematopoietic Stem Cell Transplantation
Hodgkin Disease
Humans
Lymphoma, Follicular
Male
Neoplasm Recurrence, Local
Rituximab
Transplantation, Autologous
Follicular lymphoma
Composite lymphoma
Autologous hematopoietic stem cell transformation
Classic Hodgkin lymphoma
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Summary:There are few reports of a patient presenting with combined follicular lymphoma (FL) and classical Hodgkin lymphoma (cHL). A 37-year-old Japanese man was diagnosed with FL with generalized lymphadenopathy and treated with R-CHOP. Four months later, he presented with fever, elevated lactic acid dehydrogenase (LDH), and pancytopenia. Consequently, he was diagnosed with cHL in the bone marrow. Identical clonality of FL and cHL tumor cells suggested identical immunoglobulin heavy chain gene rearrangements. He was treated with salvage chemotherapy and high-dose chemotherapy with autologous hematopoietic stem cell transformation (HDT-ASCT), which has led to complete remission and no recurrence for more than two years after transplantation. Our case suggests that HDT-ASCT may be an effective treatment for this rare clinical condition.
ISSN:0485-1439
DOI:10.11406/rinketsu.61.39