大腸絨毛状腫瘍成分におけるp53蛋白発現とKi-67を指標とした増殖能の検討 腺腫内癌, 進行癌と比較して
大腸絨毛状腫瘍成分の生物学的特性を検索する目的で, 絨毛状腫瘍成分を50%以上を有する腺腫10症例をp53蛋白発現とKi-67標識率を指標とする増殖能の視点から, 免疫組織化学的検討を行った. 対照として大腸腺腫内癌18例, 深達度mp以上の進行癌39例を用いた. p53蛋白発現率は絨毛状腫瘍成分の腺腫部では0%, 癌部では20%であり, 腺腫内癌の腺腫部では33%, 癌部では61%であった. Ki-67標識率では絨毛状腺腫成分はそれぞれの癌に比べ, 有意に低く, また, 腺腫内癌の腺腫部に比べても有意に低値であった. それに反し, 絨毛状癌成分では腺腫内癌の癌部とほぼ類似していた. 絨毛状腺...
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| Published in | 日本消化器外科学会雑誌 Vol. 29; no. 3; pp. 704 - 709 |
|---|---|
| Main Authors | , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
一般社団法人 日本消化器外科学会
01.03.1996
一般社団法人日本消化器外科学会 The Japanese Society of Gastroenterological Surgery |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0386-9768 1348-9372 |
| DOI | 10.5833/jjgs.29.704 |
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| Abstract | 大腸絨毛状腫瘍成分の生物学的特性を検索する目的で, 絨毛状腫瘍成分を50%以上を有する腺腫10症例をp53蛋白発現とKi-67標識率を指標とする増殖能の視点から, 免疫組織化学的検討を行った. 対照として大腸腺腫内癌18例, 深達度mp以上の進行癌39例を用いた. p53蛋白発現率は絨毛状腫瘍成分の腺腫部では0%, 癌部では20%であり, 腺腫内癌の腺腫部では33%, 癌部では61%であった. Ki-67標識率では絨毛状腺腫成分はそれぞれの癌に比べ, 有意に低く, また, 腺腫内癌の腺腫部に比べても有意に低値であった. それに反し, 絨毛状癌成分では腺腫内癌の癌部とほぼ類似していた. 絨毛状腺腫成分はp53蛋白発現とKi-67標識率の視点からは, 腺腫内癌の腺腫部に比べ, より低悪性度と推定され, 癌成分では, p53蛋白に関しては, 腺腫内癌の癌部よりは低悪性度であるが, Ki-67標識率に関しては腺腫内癌の癌部に類似するものと考えられた. |
|---|---|
| AbstractList | 大腸絨毛状腫瘍成分の生物学的特性を検索する目的で,絨毛状腫瘍成分を50%以上を有する腺腫10症例をp53蛋白発現とKi-67標識率を指標とする増殖能の視点から,免疫組織化学的検討を行った.対照として大腸腺腫内癌18例,深達度mp以上の進行癌39例を用いた.p53蛋白発現率は絨毛状腫瘍成分の腺腫部では0%,癌部では20%であり,腺腫内癌の腺腫部では33%,癌部では61%であった.ki-67標識率では絨毛状腺腫成分はそれぞれの癌に比ベ有意に低く,また,腺腫内癌の腺腫部に比べても有意に低値であった.それに反し,絨毛状癌成分では腺腫内癌の癌部とほぼ類似していた.絨毛状腺腫成分はp53蛋白発現とki-67標識率の視点からは,腺腫内癌の腺腫部に比べより低悪性度と推定され,癌成分では,p53蛋白に関しては,腺腫内癌の癌部よりは低悪性度であるが,Ki-67標識率に関しては腺腫内癌の癌部に類似するものと考えられた.
Ten cases of colonic villous tumors composed of 10 villous adenoma components and 5 villous carcinoma components were investigated in terms of p53 expression and Ki-67 proliferative activity to determine their biological characteristics on the basis of comparison with 18 cases of cancer in adenoma and 39 cases of advanced cancer. Over expression of p53 was detected in none of the villous adenoma components, in 20% of the villous carcinoma components and in 33% of adenomas and 61% of carcinomas in patients with cancer in adenoma, Ki-67 lalbeling indices of the villous adenoma components were significantly lower than those of any carcinomas examined in the present study, and also significantly lower than those of adenomas in patients with cancer in adenoma. However, the villous carcinoma components had an index similar to that of carcinoma of patients with cancer in adenoma. These findings suggested that the villous adenoma component has a low grade malignant potential compared with adenoma in patients with cancer in adenoma in terms of over expression of p53 and the Ki-67 labeling index. In contrast, villous carcinoma has a diverse malignant potential different from that of villous adenoma, but resembling that of carcinoma in patients with cancer in adenoma. 大腸絨毛状腫瘍成分の生物学的特性を検索する目的で, 絨毛状腫瘍成分を50%以上を有する腺腫10症例をp53蛋白発現とKi-67標識率を指標とする増殖能の視点から, 免疫組織化学的検討を行った. 対照として大腸腺腫内癌18例, 深達度mp以上の進行癌39例を用いた. p53蛋白発現率は絨毛状腫瘍成分の腺腫部では0%, 癌部では20%であり, 腺腫内癌の腺腫部では33%, 癌部では61%であった. Ki-67標識率では絨毛状腺腫成分はそれぞれの癌に比べ, 有意に低く, また, 腺腫内癌の腺腫部に比べても有意に低値であった. それに反し, 絨毛状癌成分では腺腫内癌の癌部とほぼ類似していた. 絨毛状腺腫成分はp53蛋白発現とKi-67標識率の視点からは, 腺腫内癌の腺腫部に比べ, より低悪性度と推定され, 癌成分では, p53蛋白に関しては, 腺腫内癌の癌部よりは低悪性度であるが, Ki-67標識率に関しては腺腫内癌の癌部に類似するものと考えられた. |
| Author | 大谷, 剛正 池永, 誠 内藤, 修 比企, 能樹 笹本, 浩 柿田, 章 |
| Author_FL | NAITOU Osamu KAKITA Akira SASAMOTO Hiroshi OHTANI Yoshimasa IKENAGA Makoto HIKI Yoshiki |
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| DocumentTitleAlternate | Expression of p53 and Ki-67 Proliferative Activity on Colonic Villous Tumors - Comparison with Cases of Cancer in Adenoma and Advanced Cancer of the Colon |
| DocumentTitle_FL | Expression of p53 and Ki-67 Proliferative Activity on Colonic Villous Tumors - Comparison with Cases of Cancer in Adenoma and Advanced Cancer of the Colon |
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| PublicationTitle_FL | Jpn. J. Gastroenterol. Surg |
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| References | 2) Jahadi MR, Baldin A: Villous adenomas of the colon and rectum. Am J Surg 130: 723-729, 1975 4) Yamagiwa H, Ishihara A, Matsuzaki O et al: Malignant transformation of adenoma in large intestin: Especially on villous adenoma. Acta Pathol Jpn 30: 427-435, 1980 20) Fearon ER, Vogelstein B: A genetic model for volorectal tumorigenesis. Cell61: 759 767, 1990 16) Finlay CA, Hinds PW, Tan TH et al: Activating mutations for transformation by p53 produce a gene product that forms an hsc 70-p53 complex with an altered half life. Mol Cell Biol 8: 531-539, 1988 21) Shepherd NA, Richman PI, England J: Ki-67 derived proliferetive activity in colorectal adnocarchinoma with prognostic correlations. J Pathol 155: 213-219, 1988 7) Gerdes J, Schwab U, Lemke H et al: Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31: 13-20, 1983 22) 寺邊政宏: 大腸癌におけるKi-67標識率 (Ki-67 score) と臨床病理学的進行度の関連についての研究. 日本大腸肛門病会誌45: 11-16, 1992 10) Isobe M, Emanuel BS, Givol D et al: Localization of gene for human p53 tumor antigen to band 17p13. Nature 320: 84-85, 1986 14) Steinmeyer K, Maacke H, Deppert W: Cell cycle control by p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. I. Regulation of p53 exxpression. Oncogene 5: 1691-1699, 1990 5) Muto T, Ishikawa K, Kino I et al: Comparative histologic study of the large intestine in Japan and England, with special reference to malignant potential. Dis Colon Rectum20: 11-16, 1977 13) Milner J, Medcalf EA: Cotranslation of activated mutant p53 with wild type drivers the wild-type p63 protein into the mutant conformation. Cell 65: 765-774, 1991 18) Pignatelli M, Stamp GWH, Karifi G et al: Overexpression of p53 nuclear oncoprotein in colorectal adenomas. Int J Cancer 50: 683-688, 1992 17) Purdie CA, O'Grady J, Piris J et al: p53 expression in colorectal tumors. Am J Pathol 138: 807-813, 1991 8) Lane DP, Crawford LV: T-antigen is bound to host protein in SV 40 transformed cells. Nature278: 261-263, 1979 1) Welch JP, Welch CE: Villous adenoma of the colorectum. Am J Surg 131: 185-191, 1976 3) 佐々木喬敏, 玉木文彦, 丸山雅一ほか: 大腸villous adenoma 37例の検討. 胃と腸17: 1151-1160, 1982 11) Finlay CA, Hinds PW, Levine AJ: The p53 proto-oncogene can act as a suppressor of transformation. Cell 57: 1083-1093, 1989 19) 小出 章: 大腸腺腫, 癌におけるp53核蛋白の免疫組織学的研究. 日本大腸肛門病会誌 46: 20-26, 1993 12) Levine AL, Momand J, Finlay CA: The p53 tumor supressor gene. Nature 351: 453-456, 1991 15) Montenarh M: Biochemical properties of the growth suppressor/oncoprotein p53. Oncogene 7: 1673-1680, 1992 6) 柳沢昭夫, 菅野晴夫, 加藤 洋: Villous adenoma-その臨床病理学的特徴とmalignant potentialについて. 臨床医9: 61-69, 1983 9) Sarnow P, Ho YS, Williams J et al: Adenovirus Elb-58kd tumor antigen and SV 40 large tumor antigen are physically associated with the same 54kd cellular protein in transfomledcells. Cell28: 387-394, 1982 23) 鈴木宏志, 松本好市, 山本純二ほか: 大腸癌におけるKi-67標識率と予後の関連. 日本大腸肛門病会誌45: 851-854, 1992 |
| References_xml | – reference: 4) Yamagiwa H, Ishihara A, Matsuzaki O et al: Malignant transformation of adenoma in large intestin: Especially on villous adenoma. Acta Pathol Jpn 30: 427-435, 1980 – reference: 9) Sarnow P, Ho YS, Williams J et al: Adenovirus Elb-58kd tumor antigen and SV 40 large tumor antigen are physically associated with the same 54kd cellular protein in transfomledcells. Cell28: 387-394, 1982 – reference: 13) Milner J, Medcalf EA: Cotranslation of activated mutant p53 with wild type drivers the wild-type p63 protein into the mutant conformation. Cell 65: 765-774, 1991 – reference: 20) Fearon ER, Vogelstein B: A genetic model for volorectal tumorigenesis. Cell61: 759 767, 1990 – reference: 10) Isobe M, Emanuel BS, Givol D et al: Localization of gene for human p53 tumor antigen to band 17p13. Nature 320: 84-85, 1986 – reference: 16) Finlay CA, Hinds PW, Tan TH et al: Activating mutations for transformation by p53 produce a gene product that forms an hsc 70-p53 complex with an altered half life. Mol Cell Biol 8: 531-539, 1988 – reference: 2) Jahadi MR, Baldin A: Villous adenomas of the colon and rectum. Am J Surg 130: 723-729, 1975 – reference: 5) Muto T, Ishikawa K, Kino I et al: Comparative histologic study of the large intestine in Japan and England, with special reference to malignant potential. Dis Colon Rectum20: 11-16, 1977 – reference: 22) 寺邊政宏: 大腸癌におけるKi-67標識率 (Ki-67 score) と臨床病理学的進行度の関連についての研究. 日本大腸肛門病会誌45: 11-16, 1992 – reference: 19) 小出 章: 大腸腺腫, 癌におけるp53核蛋白の免疫組織学的研究. 日本大腸肛門病会誌 46: 20-26, 1993 – reference: 3) 佐々木喬敏, 玉木文彦, 丸山雅一ほか: 大腸villous adenoma 37例の検討. 胃と腸17: 1151-1160, 1982 – reference: 1) Welch JP, Welch CE: Villous adenoma of the colorectum. Am J Surg 131: 185-191, 1976 – reference: 12) Levine AL, Momand J, Finlay CA: The p53 tumor supressor gene. Nature 351: 453-456, 1991 – reference: 21) Shepherd NA, Richman PI, England J: Ki-67 derived proliferetive activity in colorectal adnocarchinoma with prognostic correlations. J Pathol 155: 213-219, 1988 – reference: 7) Gerdes J, Schwab U, Lemke H et al: Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31: 13-20, 1983 – reference: 15) Montenarh M: Biochemical properties of the growth suppressor/oncoprotein p53. Oncogene 7: 1673-1680, 1992 – reference: 17) Purdie CA, O'Grady J, Piris J et al: p53 expression in colorectal tumors. Am J Pathol 138: 807-813, 1991 – reference: 11) Finlay CA, Hinds PW, Levine AJ: The p53 proto-oncogene can act as a suppressor of transformation. Cell 57: 1083-1093, 1989 – reference: 6) 柳沢昭夫, 菅野晴夫, 加藤 洋: Villous adenoma-その臨床病理学的特徴とmalignant potentialについて. 臨床医9: 61-69, 1983 – reference: 23) 鈴木宏志, 松本好市, 山本純二ほか: 大腸癌におけるKi-67標識率と予後の関連. 日本大腸肛門病会誌45: 851-854, 1992 – reference: 8) Lane DP, Crawford LV: T-antigen is bound to host protein in SV 40 transformed cells. Nature278: 261-263, 1979 – reference: 18) Pignatelli M, Stamp GWH, Karifi G et al: Overexpression of p53 nuclear oncoprotein in colorectal adenomas. Int J Cancer 50: 683-688, 1992 – reference: 14) Steinmeyer K, Maacke H, Deppert W: Cell cycle control by p53 in normal (3T3) and chemically transformed (Meth A) mouse cells. I. Regulation of p53 exxpression. Oncogene 5: 1691-1699, 1990 |
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| Snippet | 大腸絨毛状腫瘍成分の生物学的特性を検索する目的で, 絨毛状腫瘍成分を50%以上を有する腺腫10症例をp53蛋白発現とKi-67標識率を指標とする増殖能の視点から, 免疫組織化学的検討を行った. 対照として大腸腺腫内癌18例, 深達度mp以上の進行癌39例を用いた. p53蛋白発現率は絨毛状腫瘍成分の腺腫部では0%,... ... |
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| SubjectTerms | Ki-67 p53 villous tumor |
| Subtitle | 腺腫内癌, 進行癌と比較して |
| Title | 大腸絨毛状腫瘍成分におけるp53蛋白発現とKi-67を指標とした増殖能の検討 |
| URI | https://www.jstage.jst.go.jp/article/jjgs1969/29/3/29_3_704/_article/-char/ja https://cir.nii.ac.jp/crid/1571417126818227200 |
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