A case of neuroendocrine cell carcinoma of the rectum presented with an internal hemorrhoid

• Published in: Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 73; no. 6; pp. 1491 - 1496
• Main Authors: IWATA, Shingo, MASUMOTO, Hirofumi, KATURA, Hikotaro, KITAOKA, Akihiro, KATOU, Hitoshi, OKAMOTO, Eiichi, ISODA, Koutaro, OTSUKA, Kazuo
• Format: Journal Article
• Language: Japanese
• Published: Japan Surgical Association 2012
• Subjects: internal hemorrhoid; neuroendocrine cell carcinoma; rectum
• ISSN: 1345-2843; 1882-5133
• DOI: 10.3919/jjsa.73.1491

We report a case of neuroendocrine cell carcinoma of the rectum presented with an internal hemorrhoid. The case involved a 61-year-old man visited our hospital because of an internal hemorrhoid which was partially incarcerated and necrotized. Colonoscopy showed a submucosal tumor (SMT) located at the anterior aspect of the lower rectum, and the tumor was suspected to be carcinoma or carcinoid. Computed tomography of the abdomen showed a hypervascular lesion at the anterior aspect of the rectum. There were no findings suggestive of metastases to the liver and other organs. Hemorrhoidectomy and local excision were performed. Biopsy revealed a poorly differentiated adenocarcinoma (mp, INFβ, ly2, v0, and cut surface was negative for cancer). Immunohistochemistry revealed that the tumor cells were negative for cytokeranin, slightly positive for chromogranin A and remarkably positive for synaptophysin. The pathological diagnosis was neuroendocrine cell carcinoma. The Ki-67 labeling index was 80%. No metastasis and recurrence have occurred for 10 months after the first visit.