Risk Assessment of Metabolic Syndrome Using Transported Estimates in Retrospective Cohort Study

The validity of the diagnostic criteria for Metabolic Syndrome (MS) has been questioned since the syndrome was introduced. To verify their validity, the best strategy would be a cohort study. However, waist circumference (WC), which is necessary for the diagnosis of MS, was introduced to health exam...

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Bibliographic Details
Published inJapanese Journal of Biometrics Vol. 30; no. 2; pp. 93 - 104
Main Authors Ishida, Noriko, Ichimaru, Shinichiro, Hida, Ayumi, Soda, Midori, Nakamura, Tsuyoshi, Akahoshi, Masazumi
Format Journal Article
LanguageJapanese
Published The Biometric Society of Japan 31.12.2009
Subjects
metabolic syndrome
retrospective cohort study
survival analysis
transportability
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Summary:The validity of the diagnostic criteria for Metabolic Syndrome (MS) has been questioned since the syndrome was introduced. To verify their validity, the best strategy would be a cohort study. However, waist circumference (WC), which is necessary for the diagnosis of MS, was introduced to health examinations only recently. If a current regression model of WC could be transported to a previous sample, a cohort study using estimates of WC would be possible. We propose a sufficient condition for the transportability from a mathematical point of view. Using data from the Radiation Effect Research Foundation, we examined whether the proposed condition may be statistically confirmed in a real dataset. The regression model for weight, which is strongly associated with WC, was used to verify the validity of the condition. The relative risk of death from MS-related causes was obtained. The results indicated that the risk was lower with a greater WC.
ISSN:0918-4430
2185-6494
DOI:10.5691/jjb.30.93