Comparison between TRACP-5b and Serum NTX after Treatment with Risedronate in Osteoporosis

As bone metabolism markers play an important bole in evaluating the effects of osteoporosis treatment, we conducted a comparative study of TRACP-5b (Tartrate-resistant Acid Phosphatase 5b) a new biochemical marker of bone turnover and serum NTX(N-telopeptides of type I collagen) in 23 primary osteop...

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Published inOrthopedics & Traumatology Vol. 60; no. 3; pp. 473 - 476
Main Authors Tsuji, Osei, Urakado, Misao, Koyanagi, Eiichi, Shinohara, Michio, Hisae, Masayoshi, Naruo, Seiichiro, Naruo, Masakuni
Format Journal Article
LanguageJapanese
Published West-Japanese Society of Orthopedics & Traumatology 25.09.2011
Subjects
biochemical markers
osteoporosis
TRACP-5b
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Summary:As bone metabolism markers play an important bole in evaluating the effects of osteoporosis treatment, we conducted a comparative study of TRACP-5b (Tartrate-resistant Acid Phosphatase 5b) a new biochemical marker of bone turnover and serum NTX(N-telopeptides of type I collagen) in 23 primary osteoporosis patients who required bisphosphonate treatment in order to estimate the efficiency and problem of TRACP-5b.TRCP-5b levels were checked in nine patients and serum NTX in 14 patients before treatment and three months after treatment. There was higher rate of decrease in MSC(Minimum Significant Change) in the TRACP-5b group (88.9%) than the NTX group (35.7%). TRACP-5b maybe more useful than serum NTX for deciding treatment. The pre-treatment readings of three patients (33.3%) and month 3 post-treatment readings of seven patients (77.8%) were under the cutoff point for risk of fracture. This maybe due to the cutoff point itself, or because TRACP-5b is an enzyme and therefore unstable, and its activity may decrease during treatment.
ISSN:0037-1033
1349-4333
DOI:10.5035/nishiseisai.60.473