SYNTHESIS AND EFFECT OF GAMMA IRRADIATION ON SOME NEW 6,8-DICHLORO-4-(3H)-QUINAZOLINONES OF BIOLOGICAL INTEREST

Condensation of 2-phenyl-6, 8-dichloro-3, 1-benzoxazin-4-one (I) with hydrazine hydrate and some sulpha drugs gave IIa and IXa–d respectively. The 3-amino derivative (IIa) was allowed to react with acid anhydrides, phenyl isocyanate or isothiocyanate and aromatic aldehydes as well as arylsulphonyl c...

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Published inCurrent science (Bangalore) Vol. 58; no. 22; pp. 1231 - 1234
Main Authors AMMAR, Y. A., MOHAMED, Y. A., AMIN, N. E., GHORAB, M. M.
Format Journal Article
LanguageEnglish
Published CURRENT SCIENCE ASSOCIATION 20.11.1989
Subjects
Anhydrides
Chlorides
Condensation
Hydrazines
Infrared radiation
Irradiation
Isocyanates
Phenyls
Radiation chemistry
Spectral bands
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Summary:Condensation of 2-phenyl-6, 8-dichloro-3, 1-benzoxazin-4-one (I) with hydrazine hydrate and some sulpha drugs gave IIa and IXa–d respectively. The 3-amino derivative (IIa) was allowed to react with acid anhydrides, phenyl isocyanate or isothiocyanate and aromatic aldehydes as well as arylsulphonyl chloride to give IVa, b, Va, b, VIa–d and VIIIa, b respectively. Thiazolidinones (VIIa, b) were obtained by the reaction of VIa, c with mercaptoacetic acid. The effect of gamma irradiation on and antibacterial activity of some of the synthesized compounds are described here.
ISSN:0011-3891