Synthesis of fatty hydroxamic acids catalyzed by the lipase ofMucor miehei

Biotechnological synthesis of a new class of amphiphilic molecules—fatty hydroxamic acids—was carried out using the lipase ofMucor miehei by reacting hydroxyl amine with the fatty acids in their free or methyl ester form. Concurrently with enzymatic synthesis, chemical synthesis of hydroxamic fatty...

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Bibliographic Details
Published inJournal of the American Oil Chemists' Society Vol. 67; no. 10; pp. 646 - 649
Main Authors Servat, F., Montet, D., Pina, M., Galzy, P., Arnaud, A., Ledon, H., Marcou, L., Graille, J.
Format Journal Article
LanguageEnglish
Japanese
Published Berlin/Heidelberg Springer‐Verlag 01.10.1990
Subjects
Amide
fatty
fatty acid
hydroxamic acids
lipase
synthesis
triglyceride
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Summary:Biotechnological synthesis of a new class of amphiphilic molecules—fatty hydroxamic acids—was carried out using the lipase ofMucor miehei by reacting hydroxyl amine with the fatty acids in their free or methyl ester form. Concurrently with enzymatic synthesis, chemical synthesis of hydroxamic fatty acids has also been developed by adapting methods that already existed for water‐soluble acids. Different parameters were studied to determine the optimum operating conditions: temperature, molar ratio of reagents, quantity of biocatalyst and length of reaction. A general method, whatever the type of fatty acids used, is described.
ISSN:0003-021X
1558-9331
DOI:10.1007/BF02540415