Comparative Study of Sex Differences Due to a High-Fat Diet on Body Composition and Bone Strength of Lumbar Vertebrae in Young Adult Rats

  There is a sex difference in the development of metabolic disorders due to obesity. We aimed to compare the influences of high-fat diet feeding on body composition and bone strength of lumbar vertebrae between male and female rats. Eleven-week-old Sprague-Dawley strain young adult male and female...

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Published inJournal of Home Economics of Japan Vol. 74; no. 2; pp. 76 - 83
Main Authors OKU, Yuno, NODA, Seiko, YAMADA, Asako, NAKAOKA, Kanae, (SONE), Masae GOSEKI
Format Journal Article
LanguageEnglish
Published The Japan Society of Home Economics 2023
Subjects
body composition
bone strength
calcium balance
sex differences
young adult rats
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Summary:  There is a sex difference in the development of metabolic disorders due to obesity. We aimed to compare the influences of high-fat diet feeding on body composition and bone strength of lumbar vertebrae between male and female rats. Eleven-week-old Sprague-Dawley strain young adult male and female rats were divided into two groups to receive a basic control diet (Cont.) or high-fat diet (HF). At 28 days after feeding them the experimental diets, the weights of visceral fat mass were higher in the HF group than Cont. groups in both male and female rats. Interestingly, these indicators of bone strength of female rats in the HF group were significantly lower than in the Cont. group, but this was not significant in male rats. In conclusion, the decrease in bone strength of the lumbar vertebrae due to a high-fat diet for 28 days was shown to be more notable in female rats than in male rats. Further research is necessary concerning the effects of a high-fat diet on the regulation of bone metabolism.
ISSN:0913-5227
1882-0352
DOI:10.11428/jhej.74.76