ターゲティングを用いたMRI造影剤

MRI造影剤，特に対象部位のみを選択的に画像化できる造影剤に，ターゲティング研究の成果が積極的に用いられはじめている．この状況は，DDSと分子イメージングが融合する領域で，今後の大きな発展が期待される．本総説は，DDS側からみてこの融合領域にどのようにアプローチしうるかについて，筆者らの研究例を盛り込んで解説した．具体的には，選択的MRI造影剤の概念，薬物と造影剤の場合のターゲティングの相違点，造影剤で選択性を得る方法，高分子ミセルキャリアを用いた造影剤の研究例である．...

Full description

Saved in:
Bibliographic Details
Published inDrug Delivery System Vol. 23; no. 1; pp. 33 - 39
Main Authors 横山, 昌幸, 白石, 貢一
Format Journal Article
LanguageJapanese
Published 日本DDS学会 01.01.2008
Online AccessGet full text
ISSN0913-5006
1881-2732
DOI10.2745/dds.23.33

Cover

Abstract MRI造影剤，特に対象部位のみを選択的に画像化できる造影剤に，ターゲティング研究の成果が積極的に用いられはじめている．この状況は，DDSと分子イメージングが融合する領域で，今後の大きな発展が期待される．本総説は，DDS側からみてこの融合領域にどのようにアプローチしうるかについて，筆者らの研究例を盛り込んで解説した．具体的には，選択的MRI造影剤の概念，薬物と造影剤の場合のターゲティングの相違点，造影剤で選択性を得る方法，高分子ミセルキャリアを用いた造影剤の研究例である．
AbstractList MRI造影剤，特に対象部位のみを選択的に画像化できる造影剤に，ターゲティング研究の成果が積極的に用いられはじめている．この状況は，DDSと分子イメージングが融合する領域で，今後の大きな発展が期待される．本総説は，DDS側からみてこの融合領域にどのようにアプローチしうるかについて，筆者らの研究例を盛り込んで解説した．具体的には，選択的MRI造影剤の概念，薬物と造影剤の場合のターゲティングの相違点，造影剤で選択性を得る方法，高分子ミセルキャリアを用いた造影剤の研究例である．
Author 白石, 貢一
横山, 昌幸
Author_xml – sequence: 1
  fullname: 横山, 昌幸
  organization: 神奈川科学技術アカデミー横山「高分子ナノメディカル」プロジェクト
– sequence: 1
  fullname: 白石, 貢一
  organization: 神奈川科学技術アカデミー横山「高分子ナノメディカル」プロジェクト
BookMark eNo9j8tKw0AYRgepYFpd-CAT_5l_JslsBCleChVBdD1MZhJtqFWSbtzZRApuxb2CLlx62So-zFDEt7BQcXO-xYEPTpu0RuejjJB1BiGPhdxwrgo5hohLJGBJwiiPkbdIAIohlQDRCmlXVQEg5pIFhPr6yzcfvn7zzdTXj7559_WLr2-_75795NpP7vcPez9XD7PP19nN0ypZzs2wytb-tkOOd7aPunu0f7Db6271acFARFQqVJwpkTnkQsjUArcRWGldYh1n4AAtujiFVDqjQOaxiFQU5yClEVZw7JDNxW9Rjc1Jpi_KwZkpL7UpxwM7zPS8UnPUbAHEf2FPTakLg7-VBlu-
ContentType Journal Article
Copyright 2008 日本DDS学会
Copyright_xml – notice: 2008 日本DDS学会
DOI 10.2745/dds.23.33
DatabaseTitleList
DeliveryMethod fulltext_linktorsrc
Discipline Pharmacy, Therapeutics, & Pharmacology
EISSN 1881-2732
EndPage 39
ExternalDocumentID article_dds_23_1_23_1_33_article_char_ja
GroupedDBID .55
2WC
3O-
53G
5GY
ACIWK
ACPRK
AFRAH
AL-
ALMA_UNASSIGNED_HOLDINGS
AUIBY
CS3
JSF
JSH
OK1
RJT
RZJ
TKC
X7M
ID FETCH-LOGICAL-j1046-59392194ed32445bc02c60c5cd8cd210d03c3d7b0b5da905f746967f055a4c423
ISSN 0913-5006
IngestDate Wed Sep 03 06:29:28 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed false
IsScholarly true
Issue 1
Language Japanese
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-j1046-59392194ed32445bc02c60c5cd8cd210d03c3d7b0b5da905f746967f055a4c423
OpenAccessLink https://www.jstage.jst.go.jp/article/dds/23/1/23_1_33/_article/-char/ja
PageCount 7
ParticipantIDs jstage_primary_article_dds_23_1_23_1_33_article_char_ja
PublicationCentury 2000
PublicationDate 20080100
PublicationDateYYYYMMDD 2008-01-01
PublicationDate_xml – month: 01
  year: 2008
  text: 20080100
PublicationDecade 2000
PublicationTitle Drug Delivery System
PublicationTitleAlternate DDS
PublicationYear 2008
Publisher 日本DDS学会
Publisher_xml – name: 日本DDS学会
References 12) Li WH, Fraser SE, Meade TJ:A calcium-sensitive magnetic resonance imaging contrast agent. J Am Chem Soc 121:1413-1414, 1999.
16) Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R:Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. J Am Chem Soc 125:10192-10193, 2003.
18) Opanasopit P et al.:Influence of serum and albumins from different species on stability of camptothecin-loaded micelles. J Controlled Release 104:313-321, 2005.
7) Lee JH, Huh YM, Jun YW, Seo JW, Jang JT et al.:Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nature Medicine 13:95-99, 2007.
9) Weissleder R, Mahmood U:Molecular imaging. Radiology 219:316-333, 2001.
8) Bogdanov Jr A, Wright SC, Marecos EM, Bogdanova A, Martin C et al.:A long-circulating co-polymer in “passive targeting” to solid tumors. J Drug Targeting 4:321-330, 1997.
1) Wang SC, Brasch RC et al.:Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent:Imaging characteristics in normal rat tissues. Radiology 175:483-488, 1990.
17) Yokoyama M et al.:Characterization and anti-cancer activity of micelle-forming polymeric anti-cancer drug, adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 50:1693-1700, 1990.
2) Schmiedel U, Brasch RC et al.:Magnetic resonance imaging of myocardinal infarction using albumin-(Gd-DTPA), a macromolecular blood-volume contrast agent in a rat model. Investigative Radiology 22:713-721, 1987.
3) Unger E, Tilcock C et al.:Biodistribution and clearance of liposomal gadlinium-DTPA. Investigative Radiology 25:638-644, 1990.
14) Chen JW, Querol SM, Bogdanov Jr A, Weissleder R:Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology 240:473-481, 2006.
10) Querol M, Bogdanov Jr A:Amplification strategies in MR imaging:activation and accumulation of sensing contrast agent. J Magn Reson Imaging 24:971-982, 2006.
15) Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R:Magnetic relaxation switches capable of sensing molecular interactions. Nature Biotechnology 20:816-820, 2002.
5) Modo M, Hoeehn M, Bulte JWM:Cellular imaging. Molecular Imaging 4:143-164, 2005.
4) Corot C, Meyer D et al.:Physical, chemical and biological evaluations of CMD-A2-Gd-DOTA. Acta Radiologica 38:Supplement 412:91-99, 1997.
6) Jaffer FA, Libby P, Weissleder R:Nanoparticle imaging of integrins on tumor cells. Circulation 116:1052-1061, 2007.
19) Nakamura E et al.:A polymeric micelle MRI contrast agent with changeable relaxivity. J Controlled Release 114:325-333, 2006.
13) Major JL, Parigi G, Luchinat C, Meade TJ:The Syntheis and in vitro testing of a zinc-activated MRI contrast agent. PNAS 104:13881-13886, 2007.
11) Moats RA, Fraser SE, Meade TJ:A “smart” magnetic resonance imaging agent that reports on specific enzymatic activity. Angew Chem Int Engl 36:726-728, 1997.
References_xml – reference: 5) Modo M, Hoeehn M, Bulte JWM:Cellular imaging. Molecular Imaging 4:143-164, 2005.
– reference: 18) Opanasopit P et al.:Influence of serum and albumins from different species on stability of camptothecin-loaded micelles. J Controlled Release 104:313-321, 2005.
– reference: 8) Bogdanov Jr A, Wright SC, Marecos EM, Bogdanova A, Martin C et al.:A long-circulating co-polymer in “passive targeting” to solid tumors. J Drug Targeting 4:321-330, 1997.
– reference: 11) Moats RA, Fraser SE, Meade TJ:A “smart” magnetic resonance imaging agent that reports on specific enzymatic activity. Angew Chem Int Engl 36:726-728, 1997.
– reference: 14) Chen JW, Querol SM, Bogdanov Jr A, Weissleder R:Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology 240:473-481, 2006.
– reference: 13) Major JL, Parigi G, Luchinat C, Meade TJ:The Syntheis and in vitro testing of a zinc-activated MRI contrast agent. PNAS 104:13881-13886, 2007.
– reference: 2) Schmiedel U, Brasch RC et al.:Magnetic resonance imaging of myocardinal infarction using albumin-(Gd-DTPA), a macromolecular blood-volume contrast agent in a rat model. Investigative Radiology 22:713-721, 1987.
– reference: 6) Jaffer FA, Libby P, Weissleder R:Nanoparticle imaging of integrins on tumor cells. Circulation 116:1052-1061, 2007.
– reference: 10) Querol M, Bogdanov Jr A:Amplification strategies in MR imaging:activation and accumulation of sensing contrast agent. J Magn Reson Imaging 24:971-982, 2006.
– reference: 16) Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R:Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. J Am Chem Soc 125:10192-10193, 2003.
– reference: 17) Yokoyama M et al.:Characterization and anti-cancer activity of micelle-forming polymeric anti-cancer drug, adriamycin-conjugated poly(ethylene glycol)-poly(aspartic acid) block copolymer. Cancer Res 50:1693-1700, 1990.
– reference: 12) Li WH, Fraser SE, Meade TJ:A calcium-sensitive magnetic resonance imaging contrast agent. J Am Chem Soc 121:1413-1414, 1999.
– reference: 15) Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R:Magnetic relaxation switches capable of sensing molecular interactions. Nature Biotechnology 20:816-820, 2002.
– reference: 4) Corot C, Meyer D et al.:Physical, chemical and biological evaluations of CMD-A2-Gd-DOTA. Acta Radiologica 38:Supplement 412:91-99, 1997.
– reference: 7) Lee JH, Huh YM, Jun YW, Seo JW, Jang JT et al.:Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nature Medicine 13:95-99, 2007.
– reference: 9) Weissleder R, Mahmood U:Molecular imaging. Radiology 219:316-333, 2001.
– reference: 3) Unger E, Tilcock C et al.:Biodistribution and clearance of liposomal gadlinium-DTPA. Investigative Radiology 25:638-644, 1990.
– reference: 19) Nakamura E et al.:A polymeric micelle MRI contrast agent with changeable relaxivity. J Controlled Release 114:325-333, 2006.
– reference: 1) Wang SC, Brasch RC et al.:Evaluation of Gd-DTPA-labeled dextran as an intravascular MR contrast agent:Imaging characteristics in normal rat tissues. Radiology 175:483-488, 1990.
SSID ssj0048811
ssib058492641
ssib007483962
ssib001535732
ssib002484529
Score 1.725841
Snippet ...
SourceID jstage
SourceType Publisher
StartPage 33
Title ターゲティングを用いたMRI造影剤
URI https://www.jstage.jst.go.jp/article/dds/23/1/23_1_33/_article/-char/ja
Volume 23
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
ispartofPNX Drug Delivery System, 2008, Vol.23(1), pp.33-39
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwELaq5cIF8RRv9YD3tClObCf20U1bLaBFC3SlvUWJ0yBVaEG77aGc2BYhcUXcQYIDRx5XEP-APxGtEP-CsZ203RWHZaXKmk4nk2nGccb2zBeEbgmRchpp5umwMNuMOvOkDApvIHhEWUEHYWYKnDfuh-tb7O423240fi1lLY1HWUs__2ddyUm8Cjzwq6mS_Q_PzpUCA2jwL7TgYWiP5WPcpVgEuN2zBMXtuOYEFUeEFUfRWobWMqQiJAhHWDKshOX4WLCKkL2Nh3dwV5p8CAXyHLc7uO0bQkis2HJo29kdP4bh64lJ9JhUSOi1O3E3NNqVsip88wHXGq4UWMSWK3FbLOTBIGlOZoieMdrKC_PPFNjLQBi7lzPN1yzEkTULqz7CilsixirudB6ZU6kOVqHVEWOplhcrfepxQirQbDdUC-GbwqJDY7mrXT7UZ93A7NA2qke8g086-vCA-bnB2cjzvVZAW_UBh7C4K08nIJMENPFdQ2lS_2BK5ZIhxOungiiyaQP3HizvSlK4A5Z2sZkw-97z7xGDcHUB3wixoYR4dZ6yBGOtfZ_0_Go4pCxj9-251RBJDWFeUeck2jCpfxadqeY3TeUsPYcaw_Q8Wt10AOmTtWZ_Ue-3t9ZcbW4uoNMnF5BXTn-Ws-_l9Gs5e1VOP5Szb-X0czl98_vtp3L_Zbn_DvrjnxfvD358OXj98SLa6nX78bpXvdDDG5pUAo9LiMZ9yQY5hPGMZ5oEOiTa4lPkgU9yQjXNo4xkPE8l4UXEQhlGBeE8ZRoC_0toZefpzuAyamZ5IVOiU5ZpwXKzfgmRd5GmoJnoTOgrKHKXIXnmUFuS4_ru6omPvIZOLzr7dbQy2h0PbkDIOspu2n7wF0OsgNM
linkProvider Colorado Alliance of Research Libraries
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=%E3%82%BF%E3%83%BC%E3%82%B2%E3%83%86%E3%82%A3%E3%83%B3%E3%82%B0%E3%82%92%E7%94%A8%E3%81%84%E3%81%9FMRI%E9%80%A0%E5%BD%B1%E5%89%A4&rft.jtitle=Drug+Delivery+System&rft.au=%E6%A8%AA%E5%B1%B1%2C+%E6%98%8C%E5%B9%B8&rft.au=%E7%99%BD%E7%9F%B3%2C+%E8%B2%A2%E4%B8%80&rft.date=2008-01-01&rft.pub=%E6%97%A5%E6%9C%ACDDS%E5%AD%A6%E4%BC%9A&rft.issn=0913-5006&rft.eissn=1881-2732&rft.volume=23&rft.issue=1&rft.spage=33&rft.epage=39&rft_id=info:doi/10.2745%2Fdds.23.33&rft.externalDocID=article_dds_23_1_23_1_33_article_char_ja
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0913-5006&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0913-5006&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0913-5006&client=summon