Fundamental Study on Occlusion Therapy of Newborn Vessels by Magnetic Force Control

• Published in: Transactions of Japanese Society for Medical and Biological Engineering Vol. Annual59; no. Abstract; p. 334
• Main Authors: Tokumaru, Yugo, Kirimura, Makoto, Akiyama, Yoko, Manabe, Yuichiro, Sato, Fuminobu
• Format: Journal Article
• Language: Japanese
• Published: Japanese Society for Medical and Biological Engineering 2021
• ISSN: 1347-443X; 1881-4379
• DOI: 10.11239/jsmbe.Annual59.334

An occlusion therapy of newborn blood vessels by magnetic force control as a cancer treatment method was proposed. In this treatment, ferromagnetic particles are injected into blood vessels near the cancer by catheter, and then the particles accumulate and aggregate in the newborn vessels by controlling the magnetic field from outside the body. Finally, the aggregates of the particles block the newborn blood vessels, which inhibits the growth of cancer. We verified the flow blockage of simulated blood vessels by applying external magnetic field to micro-flow channel chips circulating the model blood containing the polyacrylic acid-modified magnetite particles. As the results, all the channels under magnetic field over 310 mT were occluded. This result indicates the possibility of occluding newborn blood vessels controlling external magnetic force after injection of magnetite particles. In addition, there was no effect of electrolytes in the blood on flow blockage.