P-190: The effect of accupril on circadian blood pressure patterns in hypertensive subjects with left ventricle hypertrophy

• Published in: American journal of hypertension Vol. 17; no. S1; p. 103A
• Main Authors: da Costa, Lilian Soares, Sabino, Hugo, Zajdenverg, Ricardo, Neto, Soriano de Carvalho Furtado, Neto, Cantidio Drumond, Jazbik, Antonio
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2004
• Subjects: Ambulatory Blood Pressure Monitoring; Left Ventricular Hypertrophy; Pharmacology Therapy
• ISSN: 0895-7061; 1879-1905; 1941-7225
• DOI: 10.1016/j.amjhyper.2004.03.265

Antihypertensive treatment that leads to blood pressure reduction is associated to decreased cardiovascular morbi-mortality. Among the agent that are currently available, it appears that inhibitors of the renin-angiotensin-aldosterone system are most effective. Data indicate that non-dippers with left ventricular hypertrophy (LVH) have an additional factor for cardiovascular events and higher mortality compared with dippers. In order to demonstrate whether one group of these drugs will be effective to restore the circadian blood pressure patterns in non-dippers hypertensive subjects, we select 18 hypertensive aged 40 to 55 years old who present LVH demonstrated by echocardiography measurements. We studied two groups, 10 non-dipper (42±5years) and 8 dippers (44±4years) demonstrated by ambulatory blood pressure monitoring (ABPM). The distribution of age, body mass index, biochemical parameters and daytime systolic and diastolic blood pressure are similar between groups. We demonstrated that non-dippers have higher values of left ventricular mass compared with dippers (p<0.05), despite having no significant difference on daytime arterial blood pressure values (p=0,559). In our study both groups were submitted to Accupril® treatment in order to observe the ABPM profile. We demonstrated the same significant reduction in systolic (p<0.001) and diastolic (p<0.05) daytime blood pressure in both groups and a significant reduction in nighttime blood pressure only in non-dipper group (p<0.05). The non-dipper group was found to have improved their nighttime profile independent of daytime blood pressure, leading the supposition that this drug coud have beneficial and additional effects on nighttime blood pressure patterns in non-dippers hypertensive subjects. Am J Hypertens (2004) 17, 103A–103A; doi: 10.1016/j.amjhyper.2004.03.265