P-190: The effect of accupril on circadian blood pressure patterns in hypertensive subjects with left ventricle hypertrophy

Antihypertensive treatment that leads to blood pressure reduction is associated to decreased cardiovascular morbi-mortality. Among the agent that are currently available, it appears that inhibitors of the renin-angiotensin-aldosterone system are most effective. Data indicate that non-dippers with le...

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Published inAmerican journal of hypertension Vol. 17; no. S1; p. 103A
Main Authors da Costa, Lilian Soares, Sabino, Hugo, Zajdenverg, Ricardo, Neto, Soriano de Carvalho Furtado, Neto, Cantidio Drumond, Jazbik, Antonio
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 01.05.2004
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Summary:Antihypertensive treatment that leads to blood pressure reduction is associated to decreased cardiovascular morbi-mortality. Among the agent that are currently available, it appears that inhibitors of the renin-angiotensin-aldosterone system are most effective. Data indicate that non-dippers with left ventricular hypertrophy (LVH) have an additional factor for cardiovascular events and higher mortality compared with dippers. In order to demonstrate whether one group of these drugs will be effective to restore the circadian blood pressure patterns in non-dippers hypertensive subjects, we select 18 hypertensive aged 40 to 55 years old who present LVH demonstrated by echocardiography measurements. We studied two groups, 10 non-dipper (42±5years) and 8 dippers (44±4years) demonstrated by ambulatory blood pressure monitoring (ABPM). The distribution of age, body mass index, biochemical parameters and daytime systolic and diastolic blood pressure are similar between groups. We demonstrated that non-dippers have higher values of left ventricular mass compared with dippers (p<0.05), despite having no significant difference on daytime arterial blood pressure values (p=0,559). In our study both groups were submitted to Accupril® treatment in order to observe the ABPM profile. We demonstrated the same significant reduction in systolic (p<0.001) and diastolic (p<0.05) daytime blood pressure in both groups and a significant reduction in nighttime blood pressure only in non-dipper group (p<0.05). The non-dipper group was found to have improved their nighttime profile independent of daytime blood pressure, leading the supposition that this drug coud have beneficial and additional effects on nighttime blood pressure patterns in non-dippers hypertensive subjects. Am J Hypertens (2004) 17, 103A–103A; doi: 10.1016/j.amjhyper.2004.03.265
Bibliography:ark:/67375/HXZ-1R824HP5-L
href:17_S1_103Aa.pdf
istex:972BE4BD9C992F96747A3E7E327453B554FCB84D
ISSN:0895-7061
1879-1905
1941-7225
DOI:10.1016/j.amjhyper.2004.03.265