OR 59: Distribution of the metabolic syndrome risk factors in obese African american women

• Published in: American journal of hypertension Vol. 17; no. S1; pp. 25A - 26A
• Main Authors: Diep, Lien, Kwagyan, John, Maqbool, Abid, Xu, Shichen, Bettencourt, Christiana, Ketete, Muluemebet, Ordor, Debra, Tilghman, Carl, Victor, Gina, Randall, Otelio
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2004
• Subjects: African American Women; Metabolic Syndrome; Obesity
• ISSN: 0895-7061; 1879-1905; 1941-7225
• DOI: 10.1016/j.amjhyper.2004.03.058

Metabolic syndrome (MS), which includes insulin resistance, dyslipidemia (DSL), and hypertension (HTN), affects about 20% of people in the US, and is a powerful predictor of atherosclerosis. We examined the distribution of MS risk factors in obese African American women. Data consisted of 137 women, mean±SD age of 48.3±9.9 yrs and BMI of 42.9±6.8kg/m2, enrolled in a risk factor reduction program in the Clinical Research Center. Diabetes mellitus was present in 24%, HTN in 61% and DSL in 38%. The women were classified into 5 groups of BMI: 30-34.9, 35-39.9, 40-44.9, 45-49.9, ≥50kg/m2. In women, MS is characterized by at least 3 of the following features: central obesity, based on waist circumference (WC) ≥ 88cm, high-density lipoprotein cholesterol (HDL) < 50mg/dL, triglyceride (TG) ≥150mg/dL, blood pressure (BP) ≥130/85mmHg, and fasting blood sugar (BS) ≥110mg/dL. We examined the distribution and trend of MS features in the BMI groups. The most common feature of MS was WC (99%), followed by BP (40%). Mean SBP was 135 mmHg (in each BMI group mean SBP was >130 mmHg). Seventy-six % had at least two features of MS. The prevalence of MS was 36%, inspite of some being on treatment. Results are tabulated. Central obesity, a marker of insulin resistance is present in almost all of these obese women. The results emphasize the need of these women to reduce their weight and improve their lipid and non-lipid profiles, especially SBP, through life style modification. (See Table)Distribution of the Metabolic Syndrome in Obese African American Women BMI (kg/m2) N WC (cm) [%] S/DBP (mmHg) [%]* BS (mg/dL) [%] TG (mg/dL) [%] HDL(mg/dL) [%]* MS [%]* 30–34.9 14 101 ± 19 [86] 133/84 ± 11/8 [40] 107 ± 71 [21] 124 ± 60 [29] 58 ± 13 [21] 29 35–39.9 34 107 ± 10[100] 133/80 ± 15/11 [32] 110 ± 50 [24] 125 ± 94 [24] 55 ± 16 [29] 29 40–44.9 40 113 ± 13[100] 133/82 ± 20/9 [37] 98 ± 35 [18] 106 ± 36 [10] 55 ± 16 [38] 30 45–49.9 30 122 ± 12[100] 138/85 ± 20/10 [46] 96 ± 22 [13] 124 ± 54 [30] 57 ± 14 [37] 40 50> 19 130 ± 15[100] 138/84 ± 22/14 [47] 95 ± 23 [26] 102 ± 51 [16] 48 ± 15 [63] 58 Total 137 115 ± 15 [99] 135/83 ± 18/11 [40] 102 ± 40 [20] 116 ± 52 [20] 56 ± 17 [37] 36 Data are mean ± SD. [ ] indicates % with corresponding MS feature and *significant trend.