P-411: Ambulatory blood pressure, procolagen amino-terminal polypeptide (P-III-P) and hemorreologyc parameters

• Published in: American journal of hypertension Vol. 18; no. S4; pp. 154A - 155A
• Main Authors: Moreira, Carlos S., Serejo, Fatima, Alcantara, Paula, Gato-Varela, Manuel, Saldanha, Carlota, Braz-Nogueira, J.
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.05.2005
• Subjects: Haemorreologyc Parameters; Hypertension; Procolagen Amino-Terminal Polypeptide(P-III-P)
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/j.amjhyper.2005.03.429

The aim of this work is to study the relationships between blood pressure profile, cardiac manifestations of high blood pressure and P-III-P as an index of fibrosis. We studied hypertensives without other diseases using echocardiography (M and B mode, and Doppler), ABPM using a Spacelabs 9000, and plasma levels of P-III-P. The model ANOVA, one way, was used for the statistical analysis. The level of significance was accepted for p<0.01 (two-tailed probabilities). The 110 hypertensives studied were divided in two subgroups: dippers (67 subjects) and non-dippers (33 subjects). The non-dipper group had a higher degree of left ventricular hypertrophy obtained by the higher measurement of the inter-ventricular septum thickness (p<0.01), posterior wall thickness (p<0.01), and a higher index of left ventricular mass (p<0.01) then the dippers, they also have high levels of fibrinogen (p<0.01) and higher plasma levels of P-III-P then dippers (p<0.01). It was found correlation between the fibrinogen, P-III-P levels and index of left ventricular mass (p<0.01). In conclusion, P-III-P might be a marker of tissue lesion, and fibrinogen, might be a plasma marker of gravity of hypertension. This gravity can be express by the degree of left ventricular hypertrophy.