Immersion optical clearing of the human skin: in vivo studies

Summary form only given. Controlling of skin optical properties related to the immersion of refractive indices of scatterers (keratinocytes components in epidermis, collagen and elastin fibers in dermis) and ground matter is a key technique for structural and functional imaging. For in vivo studies...

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Published inSummaries of Papers Presented at the Lasers and Electro-Optics. CLEO '02. Technical Diges p. 550 vol.1
Main Authors Lakodina, N.A., Bashkatov, A.N., Genina, E.A., Sinichkin, Y.P., Tuchin, V.V., Xiangqun Xu, Wang, R.K.
Format Conference Proceeding
LanguageEnglish
Published IEEE 2002
Subjects
Dermis
Humans
In vivo
Optical control
Optical devices
Optical refraction
Optical scattering
Optical variables control
Skin
Sugar
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Summary:Summary form only given. Controlling of skin optical properties related to the immersion of refractive indices of scatterers (keratinocytes components in epidermis, collagen and elastin fibers in dermis) and ground matter is a key technique for structural and functional imaging. For in vivo studies of clearing of the human skin two optical techniques were used: reflectance spectroscopy and OCT. The intra dermis injection of 40% glucose was applied as the immersion procedure. Based on our proposed skin clearing model, we suggest that the main contribution to clearing in the first stage (first hour) is due to the refractive index matching between collagen fibrils of the dermis (n = 1.46) and the interstitial space (initially n = 1.36) to which glucose (n = 1.39) diffuses.
ISBN:1557527067
9781557527066
DOI:10.1109/CLEO.2002.1034310