Synthesis, characterization and neurotoxicity of multidentate azomethine series and their Cu(II) and Ni(II) Complexes

Two novel azomethine ligands L1 and L2 are synthesized from guanidine where L1 is (1E,3E)-1,3-bis(2,4-dihydroxybenzylidene)guanidine and L2 is (1E,3E)-1,3-bis(1-(2,4-dihydroxyphenyl)ethylidene)guanidine. The ligands are reacted with Cu(II) and Ni(II) to produce complexes CuL1, CuL2, NiL1 and NiL2. A...

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Bibliographic Details
Published in2010 International Conference on Science and Social Research (CSSR 2010) pp. 447 - 450
Main Authors Noordin, Nurdini, Bahron, Hadariah, Kassim, Karimah, Mazatulikhma Mat Zain
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.12.2010
Subjects
azomethine
Compounds
cytotoxicity assay
Ethanol
guanidine
Magnetic susceptibility
Metals
neuroblastoma SH-SY5Y cell lines
neurotoxicity
Nuclear magnetic resonance
Spectroscopy
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Summary:Two novel azomethine ligands L1 and L2 are synthesized from guanidine where L1 is (1E,3E)-1,3-bis(2,4-dihydroxybenzylidene)guanidine and L2 is (1E,3E)-1,3-bis(1-(2,4-dihydroxyphenyl)ethylidene)guanidine. The ligands are reacted with Cu(II) and Ni(II) to produce complexes CuL1, CuL2, NiL1 and NiL2. All the compounds are characterized by Fourier Transform Infrared (FTIR) spectroscopy, CHN elemental analysis, Proton Nuclear Magnetic Resonance spectroscopy and magnetic susceptibility measurements. The shift of ν(C=N) peaks upon complexation indicates that the azomethine nitrogens are involved in the chelation to the metal centres. The magnetic susceptibility measurements show that copper(II) complexes are paramagnetic with 1 unpaired electron while nickel(II) complexes are diamagnetic. An investigation for neurotoxicity against treated neuroblastoma SH-SY5Y cell lines showed non-toxic effect for the range of concentrations investigated.
ISBN:9781424489879
1424489873
DOI:10.1109/CSSR.2010.5773818