Aligned, electrospun topography for use with external stimulus systems

Variations in fiber density, diameter, and orientation can be used to direct cell migration and guide neurite growth. The characterization of electrospun fibers is essential prior to conducting further research that utilizes electrospun scaffolds to control the magnitude and direction of cell migrat...

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Bibliographic Details
Published in2011 IEEE 37th Annual Northeast Bioengineering Conference (NEBEC) pp. 1 - 2
Main Authors Quallich, S G, Rivet, C J, Gilbert, R J
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.04.2011
Subjects
Lesions
Needles
Nervous system
Scanning electron microscopy
Spinning
Wheels
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Summary:Variations in fiber density, diameter, and orientation can be used to direct cell migration and guide neurite growth. The characterization of electrospun fibers is essential prior to conducting further research that utilizes electrospun scaffolds to control the magnitude and direction of cell migration and neurite growth. The goal of this study is to create highly aligned, electrospun fibers on poly-L-lactic acid (PLLA) films in parallel and perpendicular orientations to the long axis of rectangular cover slips. Fibers were electrospun into scaffolds and scanning electron microscopy (SEM) was used to characterize fiber density and orientation. The construction of electrospun scaffolds with aligned fibers is important in guiding cell behavior.
ISBN:9781612848273
1612848273
ISSN:2160-6986
2160-7028
DOI:10.1109/NEBC.2011.5778658