Study on the stability of nanodrugs using particulate growth technique

It is known that the particulate size distribution is one of the most important characteristics for the evaluation of the stability of colloidal systems. Therefore, the particulate size parameters and polydispersity index (PDI) were evaluated immediately after the production of the nanosuspensions b...

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Published in2011 IEEE Symposium on Industrial Electronics and Applications pp. 649 - 652
Main Authors Radzuan, R., Abdul Majeed, A. B., Mohd Salleh, M. K., Hamzah, M. K.
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.09.2011
Subjects
Drugs
Industrial electronics
Milling
nanoparticulate
PDI
size-distribution
stability
Stability criteria
Thermal stability
wet-nanomilling
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Summary:It is known that the particulate size distribution is one of the most important characteristics for the evaluation of the stability of colloidal systems. Therefore, the particulate size parameters and polydispersity index (PDI) were evaluated immediately after the production of the nanosuspensions by wet nanomilling, and also at 1 week to 6 weeks of storage (when feasible) under three different temperatures (4°C, 25°C and 40°C) to monitor physical stability (particle growth). The systems remained in their colloidal particulate size range (<;1 um) for nanoparticulate drugs were observed. The PDIs of nanoparticulate drugs were obtained at below 1.0.
ISBN:1457714183
9781457714184
DOI:10.1109/ISIEA.2011.6108796