Dynamic Prediction of Cellular Responding Ion Radiation based on a modeling of P53 Stress Response Networks

P53 acts a vital role in controlling the cell cycle arrest and cell apoptosis by regulating the downstream genes and their signal pathways. To investigate the complicated responses of P53 under the continuous ion radiation (IR) in the cellular level, a dynamic model for the P53 stress response netwo...

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Bibliographic Details
Published in2007 IEEE International Conference on Control and Automation pp. 2152 - 2157
Main Authors Jinpeng Qi, Shihuang Shao, Jimei Wu
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.05.2007
Subjects
Asynchronous transfer mode
Bioinformatics
Biological system modeling
Cellular networks
DNA
DNA damage
dynamics
Feedback loop
Genomics
ion radiation(IR)
Kinetic theory
oscillations
P53
Predictive models
Stress control
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Summary:P53 acts a vital role in controlling the cell cycle arrest and cell apoptosis by regulating the downstream genes and their signal pathways. To investigate the complicated responses of P53 under the continuous ion radiation (IR) in the cellular level, a dynamic model for the P53 stress response networks is proposed. The model can be used to simulate the dynamic processes of generating the double-strand breaks (DSBs) and their repairing, and ataxia telangiectasia mutated (ATM) activation, as well as the oscillations occurring in the P53-MDM2 feedback loop. Meanwhile, the plausible outcomes of cellular response are analyzed by comparing the predictive kinetics of P53 stress response networks under different IR dose domains and radiation time.
ISBN:9781424408177
1424408172
ISSN:1948-3449
1948-3457
DOI:10.1109/ICCA.2007.4376741