Determination of Amoxicillin with Novel Rhodanine Ramification by Flow Injection Chemiluminescence

3-(4'-fluorophenyl)-5-(2'-sulfonylphenylazo)-rhodanine (4FRASP) firstly synthesized by the authors was used as chemiluminescence (CL) reagent. In acidic medium, CL was observed when amoxicillin was injected into the mixture of 4FRASP-potassium permanganate. Based on this phenomenon, a flow...

Full description

Saved in:
Bibliographic Details
Published in2009 3rd International Conference on Bioinformatics and Biomedical Engineering pp. 1 - 4
Main Authors Yu, Jinghua, Huang, Jiadong, Wan, Fu-Wei, Dai, Ping, Cui, Jian-Jie
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.06.2009
Subjects
Antibiotics
Biological tissues
Chemical analysis
Chemical elements
Chemical engineering
Chemistry
Drugs
Infrared spectra
Microorganisms
Skin
Online AccessGet full text

Cover

More Information
Summary:3-(4'-fluorophenyl)-5-(2'-sulfonylphenylazo)-rhodanine (4FRASP) firstly synthesized by the authors was used as chemiluminescence (CL) reagent. In acidic medium, CL was observed when amoxicillin was injected into the mixture of 4FRASP-potassium permanganate. Based on this phenomenon, a flow injection CL method was established for the determination of amoxicillin. The CL intensity was correlated linear with the concentration of amoxicillin over the range of 5.0times10 -8 to 2.0times10 -5 g-mL -1 and the detection limit was 4.5times10 -9 g-mL -1 . The relative standard deviation (RSD) was 1.3 % for determination of 1.0times10 -6 g-mL -1 amoxicillin (n=11). This method was applied to the determination of amoxicillin in amoxicillin capsules successfully.
ISBN:9781424429011
1424429013
ISSN:2151-7614
2151-7622
DOI:10.1109/ICBBE.2009.5162615