In vitro study on the antitumor activity of several new polyoxometalates

Polyoxometalates (POMs) are negatively charged clusters consisting of transition metals and oxygen atoms. There are two general types of POM activity, antiviral and antitumoral, have dominated the medicinal chemistry of these compounds. Based on synthesized four different kind of POMs, [Ce(H 2 O) 7...

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Published inProceedings 2011 International Conference on Human Health and Biomedical Engineering pp. 594 - 597
Main Authors Zhao Wenxiu, Wang Chuanhua, Dong Shunfu, Li Yan, Zhang Duo, Han Liqin
Format Conference Proceeding
LanguageEnglish
Published IEEE 01.08.2011
Subjects
apoptosis
Cancer
Cells (biology)
Chemistry
Compounds
Humans
Metals
Mitochondria
polyoxometalates
tumor
Tumors
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Summary:Polyoxometalates (POMs) are negatively charged clusters consisting of transition metals and oxygen atoms. There are two general types of POM activity, antiviral and antitumoral, have dominated the medicinal chemistry of these compounds. Based on synthesized four different kind of POMs, [Ce(H 2 O) 7 Cr(OH) 6 Mo 6 O 18 ] n ·4nH 2 O, [Sm(H 2 O) 7 Cr(OH) 6 Mo 6 O 18 ] n ·4nH 2 O, Eu(H 2 O) 7 Cr(OH) 6- Mo 6 O 18 ] n ·4nH 2 O, and K 6 [P 2 W 18 O 62 ]·14H 2 O, we investigate their antitumor effect in vitro. K 6 [P 2 W 18 O 62 ]·14H 2 O exerted the most strong activity. IC 50 of it for MCF-7, SKOV-3 and HepG2 were 22μmol/L, 19μmol/L and 24nmol/L respectively. Lower concentration of K 6 [P 2 W 18 O 62 ]·14H 2 O could induce HepG2 cells apoptosis. It up-regulated the expression of Bax and Bim, apoptosis promoting members in Bcl-2 family, so the mechanism of this effect may through mitochondria path way.
ISBN:1612847234
9781612847238
DOI:10.1109/HHBE.2011.6028382